THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

T-cell lymphomas are aggressive diseases associated with poor outcome. Here, the authors show that the THZ1, a CDK7 inhibitor, suppresses STAT transcriptional activity leading to apoptosis and sensitization to BCL2 inhibitors in T-cell lymphomas.

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Autores principales:	Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rosella Marullo, M. Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S. Gray, Leandro Cerchietti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9b0eca4497a40c1b2e964a28298864d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d9b0eca4497a40c1b2e964a28298864d2021-12-02T14:40:46ZTHZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors10.1038/ncomms142902041-1723https://doaj.org/article/d9b0eca4497a40c1b2e964a28298864d2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14290https://doaj.org/toc/2041-1723T-cell lymphomas are aggressive diseases associated with poor outcome. Here, the authors show that the THZ1, a CDK7 inhibitor, suppresses STAT transcriptional activity leading to apoptosis and sensitization to BCL2 inhibitors in T-cell lymphomas.Florencia CayrolPannee PraditsuktavornTharu M. FernandoNicholas KwiatkowskiRosella MarulloM. Nieves Calvo-VidalJude PhillipBenet PeraShao Ning YangKaipol TakpraditLidia RomanMarcello GaudianoRamona CrescenzoJia RuanGiorgio InghiramiTinghu ZhangGraciela CremaschiNathanael S. GrayLeandro CerchiettiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florencia Cayrol Pannee Praditsuktavorn Tharu M. Fernando Nicholas Kwiatkowski Rosella Marullo M. Nieves Calvo-Vidal Jude Phillip Benet Pera Shao Ning Yang Kaipol Takpradit Lidia Roman Marcello Gaudiano Ramona Crescenzo Jia Ruan Giorgio Inghirami Tinghu Zhang Graciela Cremaschi Nathanael S. Gray Leandro Cerchietti THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
description	T-cell lymphomas are aggressive diseases associated with poor outcome. Here, the authors show that the THZ1, a CDK7 inhibitor, suppresses STAT transcriptional activity leading to apoptosis and sensitization to BCL2 inhibitors in T-cell lymphomas.
format	article
author	Florencia Cayrol Pannee Praditsuktavorn Tharu M. Fernando Nicholas Kwiatkowski Rosella Marullo M. Nieves Calvo-Vidal Jude Phillip Benet Pera Shao Ning Yang Kaipol Takpradit Lidia Roman Marcello Gaudiano Ramona Crescenzo Jia Ruan Giorgio Inghirami Tinghu Zhang Graciela Cremaschi Nathanael S. Gray Leandro Cerchietti
author_facet	Florencia Cayrol Pannee Praditsuktavorn Tharu M. Fernando Nicholas Kwiatkowski Rosella Marullo M. Nieves Calvo-Vidal Jude Phillip Benet Pera Shao Ning Yang Kaipol Takpradit Lidia Roman Marcello Gaudiano Ramona Crescenzo Jia Ruan Giorgio Inghirami Tinghu Zhang Graciela Cremaschi Nathanael S. Gray Leandro Cerchietti
author_sort	Florencia Cayrol
title	THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
title_short	THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
title_full	THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
title_fullStr	THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
title_full_unstemmed	THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
title_sort	thz1 targeting cdk7 suppresses stat transcriptional activity and sensitizes t-cell lymphomas to bcl2 inhibitors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9b0eca4497a40c1b2e964a28298864d
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THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

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