The dynamic organization of fungal acetyl-CoA carboxylase

Acetyl-CoA carboxylases are central regulatory hubs of fatty acid metabolism and are important targets for drug development in obesity and cancer. Here, the authors demonstrate that the regulation of these highly dynamic enzymes in fungi is governed by a mechanism based on phosphorylation-dependent...

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Autores principales:	Moritz Hunkeler, Edward Stuttfeld, Anna Hagmann, Stefan Imseng, Timm Maier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9b718e918e8426ea230f06c24f81344
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spelling	oai:doaj.org-article:d9b718e918e8426ea230f06c24f813442021-12-02T14:39:49ZThe dynamic organization of fungal acetyl-CoA carboxylase10.1038/ncomms111962041-1723https://doaj.org/article/d9b718e918e8426ea230f06c24f813442016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11196https://doaj.org/toc/2041-1723Acetyl-CoA carboxylases are central regulatory hubs of fatty acid metabolism and are important targets for drug development in obesity and cancer. Here, the authors demonstrate that the regulation of these highly dynamic enzymes in fungi is governed by a mechanism based on phosphorylation-dependent conformational variability.Moritz HunkelerEdward StuttfeldAnna HagmannStefan ImsengTimm MaierNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Moritz Hunkeler Edward Stuttfeld Anna Hagmann Stefan Imseng Timm Maier The dynamic organization of fungal acetyl-CoA carboxylase
description	Acetyl-CoA carboxylases are central regulatory hubs of fatty acid metabolism and are important targets for drug development in obesity and cancer. Here, the authors demonstrate that the regulation of these highly dynamic enzymes in fungi is governed by a mechanism based on phosphorylation-dependent conformational variability.
format	article
author	Moritz Hunkeler Edward Stuttfeld Anna Hagmann Stefan Imseng Timm Maier
author_facet	Moritz Hunkeler Edward Stuttfeld Anna Hagmann Stefan Imseng Timm Maier
author_sort	Moritz Hunkeler
title	The dynamic organization of fungal acetyl-CoA carboxylase
title_short	The dynamic organization of fungal acetyl-CoA carboxylase
title_full	The dynamic organization of fungal acetyl-CoA carboxylase
title_fullStr	The dynamic organization of fungal acetyl-CoA carboxylase
title_full_unstemmed	The dynamic organization of fungal acetyl-CoA carboxylase
title_sort	dynamic organization of fungal acetyl-coa carboxylase
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d9b718e918e8426ea230f06c24f81344
work_keys_str_mv	AT moritzhunkeler thedynamicorganizationoffungalacetylcoacarboxylase AT edwardstuttfeld thedynamicorganizationoffungalacetylcoacarboxylase AT annahagmann thedynamicorganizationoffungalacetylcoacarboxylase AT stefanimseng thedynamicorganizationoffungalacetylcoacarboxylase AT timmmaier thedynamicorganizationoffungalacetylcoacarboxylase AT moritzhunkeler dynamicorganizationoffungalacetylcoacarboxylase AT edwardstuttfeld dynamicorganizationoffungalacetylcoacarboxylase AT annahagmann dynamicorganizationoffungalacetylcoacarboxylase AT stefanimseng dynamicorganizationoffungalacetylcoacarboxylase AT timmmaier dynamicorganizationoffungalacetylcoacarboxylase
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The dynamic organization of fungal acetyl-CoA carboxylase

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