Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice

Abstract Both negative and positive social experiences during sensitive life phases profoundly shape brain and behaviour. Current research is therefore increasingly focusing on mechanisms mediating the interaction between varying life experiences and the epigenome. Here, male mice grew up under eith...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carina Bodden, Daniel van den Hove, Klaus-Peter Lesch, Norbert Sachser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9be3e7d0ada445a8a61d86a13c17898
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d9be3e7d0ada445a8a61d86a13c17898
record_format	dspace
spelling	oai:doaj.org-article:d9be3e7d0ada445a8a61d86a13c178982021-12-02T12:31:50ZImpact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice10.1038/s41598-017-09292-02045-2322https://doaj.org/article/d9be3e7d0ada445a8a61d86a13c178982017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09292-0https://doaj.org/toc/2045-2322Abstract Both negative and positive social experiences during sensitive life phases profoundly shape brain and behaviour. Current research is therefore increasingly focusing on mechanisms mediating the interaction between varying life experiences and the epigenome. Here, male mice grew up under either adverse or beneficial conditions until adulthood, when they were subdivided into groups exposed to situations that either matched or mismatched previous conditions. It was investigated whether the resulting four life histories were associated with changes in anxiety-like behaviour, gene expression of selected genes involved in anxiety and stress circuits, and arginine vasopressin receptor 1a (Avpr1a) gene methylation. Varying experiences during life significantly modulated (1) anxiety-like behaviour; (2) hippocampal gene expression of Avpr1a, serotonin receptor 1a (Htr1a), monoamine oxidase A (Maoa), myelin basic protein (Mbp), glucocorticoid receptor (Nr3c1), growth hormone (Gh); and (3) hippocampal DNA methylation within the Avpr1a gene. Notably, mice experiencing early beneficial and later adverse conditions showed a most pronounced downregulation of Avpr1a expression, accompanied by low anxiety-like behaviour. This decrease in Avpr1a expression may have been, in part, a consequence of increased methylation in the Avpr1a gene. In summary, this study highlights the impact of interactive social experiences throughout life on the hippocampal epigenotype and associated behaviour.Carina BoddenDaniel van den HoveKlaus-Peter LeschNorbert SachserNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carina Bodden Daniel van den Hove Klaus-Peter Lesch Norbert Sachser Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
description	Abstract Both negative and positive social experiences during sensitive life phases profoundly shape brain and behaviour. Current research is therefore increasingly focusing on mechanisms mediating the interaction between varying life experiences and the epigenome. Here, male mice grew up under either adverse or beneficial conditions until adulthood, when they were subdivided into groups exposed to situations that either matched or mismatched previous conditions. It was investigated whether the resulting four life histories were associated with changes in anxiety-like behaviour, gene expression of selected genes involved in anxiety and stress circuits, and arginine vasopressin receptor 1a (Avpr1a) gene methylation. Varying experiences during life significantly modulated (1) anxiety-like behaviour; (2) hippocampal gene expression of Avpr1a, serotonin receptor 1a (Htr1a), monoamine oxidase A (Maoa), myelin basic protein (Mbp), glucocorticoid receptor (Nr3c1), growth hormone (Gh); and (3) hippocampal DNA methylation within the Avpr1a gene. Notably, mice experiencing early beneficial and later adverse conditions showed a most pronounced downregulation of Avpr1a expression, accompanied by low anxiety-like behaviour. This decrease in Avpr1a expression may have been, in part, a consequence of increased methylation in the Avpr1a gene. In summary, this study highlights the impact of interactive social experiences throughout life on the hippocampal epigenotype and associated behaviour.
format	article
author	Carina Bodden Daniel van den Hove Klaus-Peter Lesch Norbert Sachser
author_facet	Carina Bodden Daniel van den Hove Klaus-Peter Lesch Norbert Sachser
author_sort	Carina Bodden
title	Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
title_short	Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
title_full	Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
title_fullStr	Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
title_full_unstemmed	Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
title_sort	impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9be3e7d0ada445a8a61d86a13c17898
work_keys_str_mv	AT carinabodden impactofvaryingsocialexperiencesduringlifehistoryonbehaviourgeneexpressionandvasopressinreceptorgenemethylationinmice AT danielvandenhove impactofvaryingsocialexperiencesduringlifehistoryonbehaviourgeneexpressionandvasopressinreceptorgenemethylationinmice AT klauspeterlesch impactofvaryingsocialexperiencesduringlifehistoryonbehaviourgeneexpressionandvasopressinreceptorgenemethylationinmice AT norbertsachser impactofvaryingsocialexperiencesduringlifehistoryonbehaviourgeneexpressionandvasopressinreceptorgenemethylationinmice
_version_	1718394309563121664

Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice

Ejemplares similares