Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients

Abstract Intraocular surgery is associated with increased ocular inflammation. If maintained for a prolonged period after surgery, this inflammation can cause various complications, including subconjunctival fibrosis and bleb scarring. This clinical trial was a prospective, randomised, single-blind,...

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Autores principales:	Takehiro Matsumura, Kentaro Iwasaki, Shogo Arimura, Ryuji Takeda, Yoshihiro Takamura, Masaru Inatani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9be729e85cf4727a85f409aaa727731
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spelling	oai:doaj.org-article:d9be729e85cf4727a85f409aaa7277312021-12-02T16:31:07ZTopical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients10.1038/s41598-021-85495-w2045-2322https://doaj.org/article/d9be729e85cf4727a85f409aaa7277312021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85495-whttps://doaj.org/toc/2045-2322Abstract Intraocular surgery is associated with increased ocular inflammation. If maintained for a prolonged period after surgery, this inflammation can cause various complications, including subconjunctival fibrosis and bleb scarring. This clinical trial was a prospective, randomised, single-blind, interventional study comparing the efficacy and safety of 0.1% bromfenac sodium ophthalmic solution and 0.02% fluorometholone ophthalmic suspension in the inhibition of multiple inflammatory cytokines in the aqueous humour of 26 patients with pseudophakic eyes who had undergone phacoemulsification and intraocular lens implantation. The patients were randomly assigned to one of the trial drugs, and aqueous humour samples were collected before and after drug administration. Platelet-derived growth factor-AA levels significantly decreased in both drug groups, but they were significantly higher in the fluorometholone group than in the bromfenac group (P = 0.034). Bromfenac also significantly decreased vascular endothelial growth factor level (P = 0.0077), as well as monocyte chemoattractant protein-1 level (P = 0.013), which was elevated for a prolonged period after phacoemulsification. These data suggest that bromfenac is useful to alleviate prolonged microenvironmental alterations in the aqueous humour of pseudophakic eyes.Takehiro MatsumuraKentaro IwasakiShogo ArimuraRyuji TakedaYoshihiro TakamuraMasaru InataniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takehiro Matsumura Kentaro Iwasaki Shogo Arimura Ryuji Takeda Yoshihiro Takamura Masaru Inatani Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients
description	Abstract Intraocular surgery is associated with increased ocular inflammation. If maintained for a prolonged period after surgery, this inflammation can cause various complications, including subconjunctival fibrosis and bleb scarring. This clinical trial was a prospective, randomised, single-blind, interventional study comparing the efficacy and safety of 0.1% bromfenac sodium ophthalmic solution and 0.02% fluorometholone ophthalmic suspension in the inhibition of multiple inflammatory cytokines in the aqueous humour of 26 patients with pseudophakic eyes who had undergone phacoemulsification and intraocular lens implantation. The patients were randomly assigned to one of the trial drugs, and aqueous humour samples were collected before and after drug administration. Platelet-derived growth factor-AA levels significantly decreased in both drug groups, but they were significantly higher in the fluorometholone group than in the bromfenac group (P = 0.034). Bromfenac also significantly decreased vascular endothelial growth factor level (P = 0.0077), as well as monocyte chemoattractant protein-1 level (P = 0.013), which was elevated for a prolonged period after phacoemulsification. These data suggest that bromfenac is useful to alleviate prolonged microenvironmental alterations in the aqueous humour of pseudophakic eyes.
format	article
author	Takehiro Matsumura Kentaro Iwasaki Shogo Arimura Ryuji Takeda Yoshihiro Takamura Masaru Inatani
author_facet	Takehiro Matsumura Kentaro Iwasaki Shogo Arimura Ryuji Takeda Yoshihiro Takamura Masaru Inatani
author_sort	Takehiro Matsumura
title	Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients
title_short	Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients
title_full	Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients
title_fullStr	Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients
title_full_unstemmed	Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients
title_sort	topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d9be729e85cf4727a85f409aaa727731
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Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients

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