Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Ferroptosis is a novel form of regulated cell death (RCD) that is typically accompanied by iron accumulation and lipid peroxidation. In contrast to apoptosis, autophagy, and necroptosis, ferroptosis has unique biological processes and pathophysiological characteristics. Since it was first proposed i...

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Autores principales:	Chengfei Xu, Ziling Liu, Jiangwei Xiao
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ferroptosis ischemia/reperfusion injury inflammatory bowel disease gastric cancer colorectal cancer Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d9c0ed9a48064d7ca60c112ab21ae45a
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id	oai:doaj.org-article:d9c0ed9a48064d7ca60c112ab21ae45a
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spelling	oai:doaj.org-article:d9c0ed9a48064d7ca60c112ab21ae45a2021-11-25T17:56:20ZFerroptosis: A Double-Edged Sword in Gastrointestinal Disease10.3390/ijms2222124031422-00671661-6596https://doaj.org/article/d9c0ed9a48064d7ca60c112ab21ae45a2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12403https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Ferroptosis is a novel form of regulated cell death (RCD) that is typically accompanied by iron accumulation and lipid peroxidation. In contrast to apoptosis, autophagy, and necroptosis, ferroptosis has unique biological processes and pathophysiological characteristics. Since it was first proposed in 2012, ferroptosis has attracted attention worldwide. Ferroptosis is involved in the progression of multiple diseases and could be a novel therapeutic target in the future. Recently, tremendous progress has been made regarding ferroptosis and gastrointestinal diseases, including intestinal ischemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), gastric cancer (GC), and colorectal cancer (CRC). In this review, we summarize the recent progress on ferroptosis and its interaction with gastrointestinal diseases. Understanding the role of ferroptosis in gastrointestinal disease pathogenesis could provide novel therapeutic targets for clinical treatment.Chengfei XuZiling LiuJiangwei XiaoMDPI AGarticleferroptosisischemia/reperfusion injuryinflammatory bowel diseasegastric cancercolorectal cancerBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12403, p 12403 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferroptosis ischemia/reperfusion injury inflammatory bowel disease gastric cancer colorectal cancer Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	ferroptosis ischemia/reperfusion injury inflammatory bowel disease gastric cancer colorectal cancer Biology (General) QH301-705.5 Chemistry QD1-999 Chengfei Xu Ziling Liu Jiangwei Xiao Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease
description	Ferroptosis is a novel form of regulated cell death (RCD) that is typically accompanied by iron accumulation and lipid peroxidation. In contrast to apoptosis, autophagy, and necroptosis, ferroptosis has unique biological processes and pathophysiological characteristics. Since it was first proposed in 2012, ferroptosis has attracted attention worldwide. Ferroptosis is involved in the progression of multiple diseases and could be a novel therapeutic target in the future. Recently, tremendous progress has been made regarding ferroptosis and gastrointestinal diseases, including intestinal ischemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), gastric cancer (GC), and colorectal cancer (CRC). In this review, we summarize the recent progress on ferroptosis and its interaction with gastrointestinal diseases. Understanding the role of ferroptosis in gastrointestinal disease pathogenesis could provide novel therapeutic targets for clinical treatment.
format	article
author	Chengfei Xu Ziling Liu Jiangwei Xiao
author_facet	Chengfei Xu Ziling Liu Jiangwei Xiao
author_sort	Chengfei Xu
title	Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease
title_short	Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease
title_full	Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease
title_fullStr	Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease
title_full_unstemmed	Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease
title_sort	ferroptosis: a double-edged sword in gastrointestinal disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d9c0ed9a48064d7ca60c112ab21ae45a
work_keys_str_mv	AT chengfeixu ferroptosisadoubleedgedswordingastrointestinaldisease AT zilingliu ferroptosisadoubleedgedswordingastrointestinaldisease AT jiangweixiao ferroptosisadoubleedgedswordingastrointestinaldisease
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Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

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