Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance

Abstract The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback. Stimulation of a hair cell is mediated by displacements of its mechanosensiti...

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Autores principales:	Nikola Ciganović, Amanuel Wolde-Kidan, Tobias Reichenbach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9c5da6cb14b4793b531c31639c9f9ac
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spelling	oai:doaj.org-article:d9c5da6cb14b4793b531c31639c9f9ac2021-12-02T12:32:54ZHair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance10.1038/s41598-017-03773-y2045-2322https://doaj.org/article/d9c5da6cb14b4793b531c31639c9f9ac2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03773-yhttps://doaj.org/toc/2045-2322Abstract The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback. Stimulation of a hair cell is mediated by displacements of its mechanosensitive hair bundle which protrudes from the apical surface of the cell into a narrow fluid-filled space between reticular lamina and tectorial membrane. While hair bundles of inner hair cells are of linear shape, those of outer hair cells exhibit a distinctive V-shape. The biophysical rationale behind this morphology, however, remains unknown. Here we use analytical and computational methods to study the fluid flow across rows of differently shaped hair bundles. We find that rows of V-shaped hair bundles have a considerably reduced resistance to crossflow, and that the biologically observed shapes of hair bundles of outer hair cells are near-optimal in this regard. This observation accords with the function of outer hair cells and lends support to the recent hypothesis that inner hair cells are stimulated by a net flow, in addition to the well-established shear flow that arises from shearing between the reticular lamina and the tectorial membrane.Nikola CiganovićAmanuel Wolde-KidanTobias ReichenbachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nikola Ciganović Amanuel Wolde-Kidan Tobias Reichenbach Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
description	Abstract The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback. Stimulation of a hair cell is mediated by displacements of its mechanosensitive hair bundle which protrudes from the apical surface of the cell into a narrow fluid-filled space between reticular lamina and tectorial membrane. While hair bundles of inner hair cells are of linear shape, those of outer hair cells exhibit a distinctive V-shape. The biophysical rationale behind this morphology, however, remains unknown. Here we use analytical and computational methods to study the fluid flow across rows of differently shaped hair bundles. We find that rows of V-shaped hair bundles have a considerably reduced resistance to crossflow, and that the biologically observed shapes of hair bundles of outer hair cells are near-optimal in this regard. This observation accords with the function of outer hair cells and lends support to the recent hypothesis that inner hair cells are stimulated by a net flow, in addition to the well-established shear flow that arises from shearing between the reticular lamina and the tectorial membrane.
format	article
author	Nikola Ciganović Amanuel Wolde-Kidan Tobias Reichenbach
author_facet	Nikola Ciganović Amanuel Wolde-Kidan Tobias Reichenbach
author_sort	Nikola Ciganović
title	Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
title_short	Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
title_full	Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
title_fullStr	Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
title_full_unstemmed	Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
title_sort	hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9c5da6cb14b4793b531c31639c9f9ac
work_keys_str_mv	AT nikolaciganovic hairbundlesofcochlearouterhaircellsareshapedtominimizetheirfluiddynamicresistance AT amanuelwoldekidan hairbundlesofcochlearouterhaircellsareshapedtominimizetheirfluiddynamicresistance AT tobiasreichenbach hairbundlesofcochlearouterhaircellsareshapedtominimizetheirfluiddynamicresistance
_version_	1718393949750558720

Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance

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