Enzyme-mimetic self-catalyzed polymerization of polypeptide helices

The folding-dependent catalytic behavior of enzymes is of fundamental biological importance, yet mechanistically underexplored. Here, the authors show that an α-helix, commonly found in proteins, can facilitate its own growth through the self-catalyzed polymerization of N-carboxyanhydride in solvent...

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Autores principales:	Ziyuan Song, Hailin Fu, Ryan Baumgartner, Lingyang Zhu, Kuo-Chih Shih, Yingchun Xia, Xuetao Zheng, Lichen Yin, Christophe Chipot, Yao Lin, Jianjun Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9c8265f36f1439fbf9f3949a2e2ae98
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spelling	oai:doaj.org-article:d9c8265f36f1439fbf9f3949a2e2ae982021-12-02T17:02:15ZEnzyme-mimetic self-catalyzed polymerization of polypeptide helices10.1038/s41467-019-13502-w2041-1723https://doaj.org/article/d9c8265f36f1439fbf9f3949a2e2ae982019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13502-whttps://doaj.org/toc/2041-1723The folding-dependent catalytic behavior of enzymes is of fundamental biological importance, yet mechanistically underexplored. Here, the authors show that an α-helix, commonly found in proteins, can facilitate its own growth through the self-catalyzed polymerization of N-carboxyanhydride in solvents with low polarity.Ziyuan SongHailin FuRyan BaumgartnerLingyang ZhuKuo-Chih ShihYingchun XiaXuetao ZhengLichen YinChristophe ChipotYao LinJianjun ChengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ziyuan Song Hailin Fu Ryan Baumgartner Lingyang Zhu Kuo-Chih Shih Yingchun Xia Xuetao Zheng Lichen Yin Christophe Chipot Yao Lin Jianjun Cheng Enzyme-mimetic self-catalyzed polymerization of polypeptide helices
description	The folding-dependent catalytic behavior of enzymes is of fundamental biological importance, yet mechanistically underexplored. Here, the authors show that an α-helix, commonly found in proteins, can facilitate its own growth through the self-catalyzed polymerization of N-carboxyanhydride in solvents with low polarity.
format	article
author	Ziyuan Song Hailin Fu Ryan Baumgartner Lingyang Zhu Kuo-Chih Shih Yingchun Xia Xuetao Zheng Lichen Yin Christophe Chipot Yao Lin Jianjun Cheng
author_facet	Ziyuan Song Hailin Fu Ryan Baumgartner Lingyang Zhu Kuo-Chih Shih Yingchun Xia Xuetao Zheng Lichen Yin Christophe Chipot Yao Lin Jianjun Cheng
author_sort	Ziyuan Song
title	Enzyme-mimetic self-catalyzed polymerization of polypeptide helices
title_short	Enzyme-mimetic self-catalyzed polymerization of polypeptide helices
title_full	Enzyme-mimetic self-catalyzed polymerization of polypeptide helices
title_fullStr	Enzyme-mimetic self-catalyzed polymerization of polypeptide helices
title_full_unstemmed	Enzyme-mimetic self-catalyzed polymerization of polypeptide helices
title_sort	enzyme-mimetic self-catalyzed polymerization of polypeptide helices
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d9c8265f36f1439fbf9f3949a2e2ae98
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Enzyme-mimetic self-catalyzed polymerization of polypeptide helices

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