A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection

Malaria: Inhibiting parasite invasion of red blood cells A vaccine targeting a protein complex that allows malaria-causing parasite to enter red blood cells has been produced. Malaria caused by the parasite Plasmodium falciparum is an oft-deadly infectious disease without an effective vaccine. A tea...

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Autores principales:	Prakash Srinivasan, G. Christian Baldeviano, Kazutoyo Miura, Ababacar Diouf, Julio A. Ventocilla, Karina P. Leiva, Luis Lugo-Roman, Carmen Lucas, Sachy Orr-Gonzalez, Daming Zhu, Eileen Villasante, Lorraine Soisson, David L. Narum, Susan K. Pierce, Carole A. Long, Carter Diggs, Patrick E. Duffy, Andres G. Lescano, Louis H. Miller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d9c88e0c86564a8eab352c28fd19d3b2
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spelling	oai:doaj.org-article:d9c88e0c86564a8eab352c28fd19d3b22021-12-02T12:30:10ZA malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection10.1038/s41541-017-0015-72059-0105https://doaj.org/article/d9c88e0c86564a8eab352c28fd19d3b22017-05-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0015-7https://doaj.org/toc/2059-0105Malaria: Inhibiting parasite invasion of red blood cells A vaccine targeting a protein complex that allows malaria-causing parasite to enter red blood cells has been produced. Malaria caused by the parasite Plasmodium falciparum is an oft-deadly infectious disease without an effective vaccine. A team of researchers at the National Institutes of Health led by Prakash Srinivasan, currently at the Johns Hopkins Malaria Research Institute, United States, demonstrated the efficacy of a vaccine candidate that works by priming a host’s immune system to a parasitic protein complex required to form a junction with red blood cells, allowing entry and proliferation of the pathogen. The group’s vaccine conferred more effective protection in monkeys than prior candidates that targeted only one component of the parasitic protein complex. This research warrants a closer look into how this candidate, and others targeting the protein complex, can be used to prevent malaria in humans.Prakash SrinivasanG. Christian BaldevianoKazutoyo MiuraAbabacar DioufJulio A. VentocillaKarina P. LeivaLuis Lugo-RomanCarmen LucasSachy Orr-GonzalezDaming ZhuEileen VillasanteLorraine SoissonDavid L. NarumSusan K. PierceCarole A. LongCarter DiggsPatrick E. DuffyAndres G. LescanoLouis H. MillerNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Prakash Srinivasan G. Christian Baldeviano Kazutoyo Miura Ababacar Diouf Julio A. Ventocilla Karina P. Leiva Luis Lugo-Roman Carmen Lucas Sachy Orr-Gonzalez Daming Zhu Eileen Villasante Lorraine Soisson David L. Narum Susan K. Pierce Carole A. Long Carter Diggs Patrick E. Duffy Andres G. Lescano Louis H. Miller A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection
description	Malaria: Inhibiting parasite invasion of red blood cells A vaccine targeting a protein complex that allows malaria-causing parasite to enter red blood cells has been produced. Malaria caused by the parasite Plasmodium falciparum is an oft-deadly infectious disease without an effective vaccine. A team of researchers at the National Institutes of Health led by Prakash Srinivasan, currently at the Johns Hopkins Malaria Research Institute, United States, demonstrated the efficacy of a vaccine candidate that works by priming a host’s immune system to a parasitic protein complex required to form a junction with red blood cells, allowing entry and proliferation of the pathogen. The group’s vaccine conferred more effective protection in monkeys than prior candidates that targeted only one component of the parasitic protein complex. This research warrants a closer look into how this candidate, and others targeting the protein complex, can be used to prevent malaria in humans.
format	article
author	Prakash Srinivasan G. Christian Baldeviano Kazutoyo Miura Ababacar Diouf Julio A. Ventocilla Karina P. Leiva Luis Lugo-Roman Carmen Lucas Sachy Orr-Gonzalez Daming Zhu Eileen Villasante Lorraine Soisson David L. Narum Susan K. Pierce Carole A. Long Carter Diggs Patrick E. Duffy Andres G. Lescano Louis H. Miller
author_facet	Prakash Srinivasan G. Christian Baldeviano Kazutoyo Miura Ababacar Diouf Julio A. Ventocilla Karina P. Leiva Luis Lugo-Roman Carmen Lucas Sachy Orr-Gonzalez Daming Zhu Eileen Villasante Lorraine Soisson David L. Narum Susan K. Pierce Carole A. Long Carter Diggs Patrick E. Duffy Andres G. Lescano Louis H. Miller
author_sort	Prakash Srinivasan
title	A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection
title_short	A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection
title_full	A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection
title_fullStr	A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection
title_full_unstemmed	A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection
title_sort	malaria vaccine protects aotus monkeys against virulent plasmodium falciparum infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9c88e0c86564a8eab352c28fd19d3b2
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A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection

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