Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance...

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Autores principales:	Matthew H. Bailey, William U. Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Yize Li, Sean Kelso, MC3 Working Group, PCAWG novel somatic mutation calling methods working group, Gordon Saksena, Kyle Ellrott, Michael C. Wendl, David A. Wheeler, Gad Getz, Jared T. Simpson, Mark B. Gerstein, Li Ding, PCAWG Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9cb28829f31451aa7d92697e8efd186
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spelling	oai:doaj.org-article:d9cb28829f31451aa7d92697e8efd1862021-12-02T18:14:31ZRetrospective evaluation of whole exome and genome mutation calls in 746 cancer samples10.1038/s41467-020-18151-y2041-1723https://doaj.org/article/d9cb28829f31451aa7d92697e8efd1862020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18151-yhttps://doaj.org/toc/2041-1723With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.Matthew H. BaileyWilliam U. MeyersonLewis Jonathan DursiLiang-Bo WangGuanlan DongWen-Wei LiangAmila WeerasingheShantao LiYize LiSean KelsoMC3 Working GroupPCAWG novel somatic mutation calling methods working groupGordon SaksenaKyle EllrottMichael C. WendlDavid A. WheelerGad GetzJared T. SimpsonMark B. GersteinLi DingPCAWG ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-27 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew H. Bailey William U. Meyerson Lewis Jonathan Dursi Liang-Bo Wang Guanlan Dong Wen-Wei Liang Amila Weerasinghe Shantao Li Yize Li Sean Kelso MC3 Working Group PCAWG novel somatic mutation calling methods working group Gordon Saksena Kyle Ellrott Michael C. Wendl David A. Wheeler Gad Getz Jared T. Simpson Mark B. Gerstein Li Ding PCAWG Consortium Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
description	With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.
format	article
author	Matthew H. Bailey William U. Meyerson Lewis Jonathan Dursi Liang-Bo Wang Guanlan Dong Wen-Wei Liang Amila Weerasinghe Shantao Li Yize Li Sean Kelso MC3 Working Group PCAWG novel somatic mutation calling methods working group Gordon Saksena Kyle Ellrott Michael C. Wendl David A. Wheeler Gad Getz Jared T. Simpson Mark B. Gerstein Li Ding PCAWG Consortium
author_facet	Matthew H. Bailey William U. Meyerson Lewis Jonathan Dursi Liang-Bo Wang Guanlan Dong Wen-Wei Liang Amila Weerasinghe Shantao Li Yize Li Sean Kelso MC3 Working Group PCAWG novel somatic mutation calling methods working group Gordon Saksena Kyle Ellrott Michael C. Wendl David A. Wheeler Gad Getz Jared T. Simpson Mark B. Gerstein Li Ding PCAWG Consortium
author_sort	Matthew H. Bailey
title	Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
title_short	Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
title_full	Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
title_fullStr	Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
title_full_unstemmed	Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
title_sort	retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d9cb28829f31451aa7d92697e8efd186
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

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