Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration

The repair of bone defects in load-bearing positions still faces great challenges. Tantalum (Ta) has attempted to repair bone defects based on the excellent mechanical properties. However, the osseointegration of Ta needs to be improved due to the lack of osteoinduction. Herein, tantalum–gelatin–met...

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Autores principales:	Fujian Zhao, Xiongfa Ji, Yang Yan, Zhen Yang, Xiaofeng Chen, Limin Ma
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tantalum bioactive glass osteointegration chemical crosslinking bone tissue engineering Technology T
Acceso en línea:	https://doaj.org/article/d9ce89326b444def8b8a7870175f9a3d
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spelling	oai:doaj.org-article:d9ce89326b444def8b8a7870175f9a3d2021-11-10T07:43:20ZFabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration2296-801610.3389/fmats.2021.701268https://doaj.org/article/d9ce89326b444def8b8a7870175f9a3d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmats.2021.701268/fullhttps://doaj.org/toc/2296-8016The repair of bone defects in load-bearing positions still faces great challenges. Tantalum (Ta) has attempted to repair bone defects based on the excellent mechanical properties. However, the osseointegration of Ta needs to be improved due to the lack of osteoinduction. Herein, tantalum–gelatin–methacryloyl–bioactive glass (Ta–GelMA–BG) scaffolds were successfully fabricated by loading BG in 3D-printed Ta scaffolds through a chemical crosslinking method. The results showed that the composite scaffolds have the ability to promote cell adhesion and proliferation. The incorporation of BG resulted in a significant increase in apatite-forming and osteogenesis differentiation abilities. In vivo results indicated that the Ta–GelMA–BG scaffolds significantly enhanced the osteointegration at the early stage after implantation. Overall, the Ta–GelMA–BG scaffolds are a promising platform for the load bearing bone regeneration field.Fujian ZhaoXiongfa JiYang YanYang YanZhen YangZhen YangXiaofeng ChenXiaofeng ChenLimin MaFrontiers Media S.A.articletantalumbioactive glassosteointegrationchemical crosslinkingbone tissue engineeringTechnologyTENFrontiers in Materials, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tantalum bioactive glass osteointegration chemical crosslinking bone tissue engineering Technology T
spellingShingle	tantalum bioactive glass osteointegration chemical crosslinking bone tissue engineering Technology T Fujian Zhao Xiongfa Ji Yang Yan Yang Yan Zhen Yang Zhen Yang Xiaofeng Chen Xiaofeng Chen Limin Ma Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration
description	The repair of bone defects in load-bearing positions still faces great challenges. Tantalum (Ta) has attempted to repair bone defects based on the excellent mechanical properties. However, the osseointegration of Ta needs to be improved due to the lack of osteoinduction. Herein, tantalum–gelatin–methacryloyl–bioactive glass (Ta–GelMA–BG) scaffolds were successfully fabricated by loading BG in 3D-printed Ta scaffolds through a chemical crosslinking method. The results showed that the composite scaffolds have the ability to promote cell adhesion and proliferation. The incorporation of BG resulted in a significant increase in apatite-forming and osteogenesis differentiation abilities. In vivo results indicated that the Ta–GelMA–BG scaffolds significantly enhanced the osteointegration at the early stage after implantation. Overall, the Ta–GelMA–BG scaffolds are a promising platform for the load bearing bone regeneration field.
format	article
author	Fujian Zhao Xiongfa Ji Yang Yan Yang Yan Zhen Yang Zhen Yang Xiaofeng Chen Xiaofeng Chen Limin Ma
author_facet	Fujian Zhao Xiongfa Ji Yang Yan Yang Yan Zhen Yang Zhen Yang Xiaofeng Chen Xiaofeng Chen Limin Ma
author_sort	Fujian Zhao
title	Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration
title_short	Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration
title_full	Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration
title_fullStr	Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration
title_full_unstemmed	Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration
title_sort	fabrication and characterization of ta–gelma–bg scaffolds by chemical crosslinking processing for promotion osteointegration
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d9ce89326b444def8b8a7870175f9a3d
work_keys_str_mv	AT fujianzhao fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration AT xiongfaji fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration AT yangyan fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration AT yangyan fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration AT zhenyang fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration AT zhenyang fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration AT xiaofengchen fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration AT xiaofengchen fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration AT liminma fabricationandcharacterizationoftagelmabgscaffoldsbychemicalcrosslinkingprocessingforpromotionosteointegration
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Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration

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