Integrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury

The diagnosis of the severity of spinal cord injury (SCI) and the revelation of potential therapeutic targets are crucial for urgent clinical care and improved patient outcomes. Here, we analyzed the overall gene expression data in peripheral blood leukocytes during the acute injury phase collected...

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Autores principales:	Shanzheng Wang, Xinhui Xie, Chao Li, Jun Jia, Changhong Chen
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	n<sup>6</sup> methylation spinal cord injury lncrna therapeutic targets network analysis Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/d9d6a821bcf74fad98ad6a3cc1fcb3db
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spelling	oai:doaj.org-article:d9d6a821bcf74fad98ad6a3cc1fcb3db2021-11-24T01:01:46ZIntegrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury10.3934/mbe.20214051551-0018https://doaj.org/article/d9d6a821bcf74fad98ad6a3cc1fcb3db2021-09-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021405?viewType=HTMLhttps://doaj.org/toc/1551-0018The diagnosis of the severity of spinal cord injury (SCI) and the revelation of potential therapeutic targets are crucial for urgent clinical care and improved patient outcomes. Here, we analyzed the overall gene expression data in peripheral blood leukocytes during the acute injury phase collected from Gene Expression Omnibus (GEO) and identified six m6A regulators specifically expressed in SCI compared to normal samples. LncRNA-mRNA network analysis identified AKT2/3 and PIK3R1 related to m6A methylation as potential therapeutic targets for SCI and constructed a classifier to identify patients of SCI to assist clinical diagnosis. Moreover, FTO (eraser) and RBMX (reader) were found to be significantly down-regulated in SCI and the functional gene co-expressed with them was found to be involved in the signal transduction of multiple pathways related to nerve injury. Through the construction of the drug-target gene network, eight key genes were identified as drug targets and it was emphasized that fostamatinib can be used as a potential drug for the treatment of SCI. Taken together, our study characterized the pathogenesis and identified a potential therapeutic target of SCI providing theoretical support for the development of precision medicine.Shanzheng WangXinhui XieChao LiJun JiaChanghong Chen AIMS Pressarticlen<sup>6</sup> methylationspinal cord injurylncrnatherapeutic targetsnetwork analysisBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 8174-8187 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	n<sup>6</sup> methylation spinal cord injury lncrna therapeutic targets network analysis Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	n<sup>6</sup> methylation spinal cord injury lncrna therapeutic targets network analysis Biotechnology TP248.13-248.65 Mathematics QA1-939 Shanzheng Wang Xinhui Xie Chao Li Jun Jia Changhong Chen Integrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury
description	The diagnosis of the severity of spinal cord injury (SCI) and the revelation of potential therapeutic targets are crucial for urgent clinical care and improved patient outcomes. Here, we analyzed the overall gene expression data in peripheral blood leukocytes during the acute injury phase collected from Gene Expression Omnibus (GEO) and identified six m6A regulators specifically expressed in SCI compared to normal samples. LncRNA-mRNA network analysis identified AKT2/3 and PIK3R1 related to m6A methylation as potential therapeutic targets for SCI and constructed a classifier to identify patients of SCI to assist clinical diagnosis. Moreover, FTO (eraser) and RBMX (reader) were found to be significantly down-regulated in SCI and the functional gene co-expressed with them was found to be involved in the signal transduction of multiple pathways related to nerve injury. Through the construction of the drug-target gene network, eight key genes were identified as drug targets and it was emphasized that fostamatinib can be used as a potential drug for the treatment of SCI. Taken together, our study characterized the pathogenesis and identified a potential therapeutic target of SCI providing theoretical support for the development of precision medicine.
format	article
author	Shanzheng Wang Xinhui Xie Chao Li Jun Jia Changhong Chen
author_facet	Shanzheng Wang Xinhui Xie Chao Li Jun Jia Changhong Chen
author_sort	Shanzheng Wang
title	Integrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury
title_short	Integrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury
title_full	Integrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury
title_fullStr	Integrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury
title_full_unstemmed	Integrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury
title_sort	integrative network analysis of n<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/d9d6a821bcf74fad98ad6a3cc1fcb3db
work_keys_str_mv	AT shanzhengwang integrativenetworkanalysisofnsup6supmethylationrelatedgenesrevealpotentialtherapeutictargetsforspinalcordinjury AT xinhuixie integrativenetworkanalysisofnsup6supmethylationrelatedgenesrevealpotentialtherapeutictargetsforspinalcordinjury AT chaoli integrativenetworkanalysisofnsup6supmethylationrelatedgenesrevealpotentialtherapeutictargetsforspinalcordinjury AT junjia integrativenetworkanalysisofnsup6supmethylationrelatedgenesrevealpotentialtherapeutictargetsforspinalcordinjury AT changhongchen integrativenetworkanalysisofnsup6supmethylationrelatedgenesrevealpotentialtherapeutictargetsforspinalcordinjury
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Integrative network analysis of N<sup>6</sup> methylation-related genes reveal potential therapeutic targets for spinal cord injury

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