Skin fibroblasts from patients with type 1 diabetes (T1D) can be chemically transdifferentiated into insulin-expressing clusters: a transgene-free approach.

Skin fibroblasts from patients with type 1 diabetes (T1D) can be chemically transdifferentiated into insulin-expressing clusters: a transgene-free approach.

The conversion of differentiated cells into insulin-producing cells is a promising approach for the autologous replacement of pancreatic cells in patients with type 1 diabetes (T1D). At present, cellular reprogramming strategies encompass ethical problems, epigenetic failure or teratoma formation, w...

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Main Authors: Federico Pereyra-Bonnet, María L Gimeno, Nelson R Argumedo, Marcelo Ielpi, Johana A Cardozo, Carla A Giménez, Sung-Ho Hyon, Marta Balzaretti, Mónica Loresi, Patricia Fainstein-Day, León E Litwak, Pablo F Argibay
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/d9dd9b23694d426caa0c1df6aa3f4827
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