Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population

Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population

Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leuko...

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Autores principales: Xuling Chang, Resham L. Gurung, Ling Wang, Aizhen Jin, Zheng Li, Renwei Wang, Kenneth B. Beckman, Jennifer Adams-Haduch, Wee Yang Meah, Kar Seng Sim, Weng Khong Lim, Sonia Davila, Patrick Tan, Jing Xian Teo, Khung Keong Yeo, Yiamunaa M., Sylvia Liu, Su Chi Lim, Jianjun Liu, Rob M. van Dam, Yechiel Friedlander, Woon-Puay Koh, Jian-Min Yuan, Chiea Chuen Khor, Chew-Kiat Heng, Rajkumar Dorajoo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/d9e076b9b5cf4b79a5a972b56a383c9a
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spelling oai:doaj.org-article:d9e076b9b5cf4b79a5a972b56a383c9a2021-12-02T15:38:22ZLow frequency variants associated with leukocyte telomere length in the Singapore Chinese population10.1038/s42003-021-02056-72399-3642https://doaj.org/article/d9e076b9b5cf4b79a5a972b56a383c9a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02056-7https://doaj.org/toc/2399-3642Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leukocyte telomere length and report a mechanistic pathway linking TERF1, leukocyte telomere length and incident colon cancer.Xuling ChangResham L. GurungLing WangAizhen JinZheng LiRenwei WangKenneth B. BeckmanJennifer Adams-HaduchWee Yang MeahKar Seng SimWeng Khong LimSonia DavilaPatrick TanJing Xian TeoKhung Keong YeoYiamunaa M.Sylvia LiuSu Chi LimJianjun LiuRob M. van DamYechiel FriedlanderWoon-Puay KohJian-Min YuanChiea Chuen KhorChew-Kiat HengRajkumar DorajooNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Xuling Chang
Resham L. Gurung
Ling Wang
Aizhen Jin
Zheng Li
Renwei Wang
Kenneth B. Beckman
Jennifer Adams-Haduch
Wee Yang Meah
Kar Seng Sim
Weng Khong Lim
Sonia Davila
Patrick Tan
Jing Xian Teo
Khung Keong Yeo
Yiamunaa M.
Sylvia Liu
Su Chi Lim
Jianjun Liu
Rob M. van Dam
Yechiel Friedlander
Woon-Puay Koh
Jian-Min Yuan
Chiea Chuen Khor
Chew-Kiat Heng
Rajkumar Dorajoo
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
description Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leukocyte telomere length and report a mechanistic pathway linking TERF1, leukocyte telomere length and incident colon cancer.
format article
author Xuling Chang
Resham L. Gurung
Ling Wang
Aizhen Jin
Zheng Li
Renwei Wang
Kenneth B. Beckman
Jennifer Adams-Haduch
Wee Yang Meah
Kar Seng Sim
Weng Khong Lim
Sonia Davila
Patrick Tan
Jing Xian Teo
Khung Keong Yeo
Yiamunaa M.
Sylvia Liu
Su Chi Lim
Jianjun Liu
Rob M. van Dam
Yechiel Friedlander
Woon-Puay Koh
Jian-Min Yuan
Chiea Chuen Khor
Chew-Kiat Heng
Rajkumar Dorajoo
author_facet Xuling Chang
Resham L. Gurung
Ling Wang
Aizhen Jin
Zheng Li
Renwei Wang
Kenneth B. Beckman
Jennifer Adams-Haduch
Wee Yang Meah
Kar Seng Sim
Weng Khong Lim
Sonia Davila
Patrick Tan
Jing Xian Teo
Khung Keong Yeo
Yiamunaa M.
Sylvia Liu
Su Chi Lim
Jianjun Liu
Rob M. van Dam
Yechiel Friedlander
Woon-Puay Koh
Jian-Min Yuan
Chiea Chuen Khor
Chew-Kiat Heng
Rajkumar Dorajoo
author_sort Xuling Chang
title Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
title_short Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
title_full Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
title_fullStr Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
title_full_unstemmed Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
title_sort low frequency variants associated with leukocyte telomere length in the singapore chinese population
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d9e076b9b5cf4b79a5a972b56a383c9a
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