Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity

Seiji Saito, Keisei Maekawa, Shigeru KotakeInstitute of Rheumatology, Tokyo Women&rsquo;s Medical University, Tokyo, JapanAbstract: Sodium hyaluronate (Na-HA) is a therapeutic agent used for treating knee arthritis. However, it has been unsuccessfully used in the treatment of knee effusions....

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Autores principales:	Seiji Saito, Keisei Maekawa, Shigeru Kotake
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d9e3084f9bd74caba0437ca97f4471e9
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spelling	oai:doaj.org-article:d9e3084f9bd74caba0437ca97f4471e92021-12-02T00:49:38ZInhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity1178-7031https://doaj.org/article/d9e3084f9bd74caba0437ca97f4471e92009-11-01T00:00:00Zhttp://www.dovepress.com/inhibitory-effects-of-zinc-hyaluronate-on-synoviocyte-growth-and-matri-a3740https://doaj.org/toc/1178-7031Seiji Saito, Keisei Maekawa, Shigeru KotakeInstitute of Rheumatology, Tokyo Women&rsquo;s Medical University, Tokyo, JapanAbstract: Sodium hyaluronate (Na-HA) is a therapeutic agent used for treating knee arthritis. However, it has been unsuccessfully used in the treatment of knee effusions. Joint effusion results from synovial activation and growth, leading to an increase in the production of matrix metalloproteinases (MMPs), especially MMP-9. This study aimed to determine whether the newly developed zinc hyaluronate (Zn-HA) is more effective than Na-HA in inhibiting the growth of synoviocytes or production and activity of MMPs in rheumatoid synoviocytes. Our results showed that Zn-HA inhibited synoviocyte growth, MMP-9 protein production, and MMP-9 mRNA expression, whereas Na-HA exerted only a slight inhibitory effect on these parameters. Moreover, Zn-HA induced synoviocyte apoptosis, whereas Na-HA did not. These results suggest that Zn-HA retards synoviocyte growth by inducing apoptosis following a decrease in the production of MMP-9 and mRNA. Therefore, it is suggested that Zn-HA can suppress arthritis more efficiently than Na-HA.Keywords: synoviocyte, apoptosis, sodium hyaluronate, zinc hyaluronate, rheumatoid arthritis, MMP-9 Seiji SaitoKeisei MaekawaShigeru KotakeDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2009, Iss default, Pp 45-57 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Seiji Saito Keisei Maekawa Shigeru Kotake Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity
description	Seiji Saito, Keisei Maekawa, Shigeru KotakeInstitute of Rheumatology, Tokyo Women&rsquo;s Medical University, Tokyo, JapanAbstract: Sodium hyaluronate (Na-HA) is a therapeutic agent used for treating knee arthritis. However, it has been unsuccessfully used in the treatment of knee effusions. Joint effusion results from synovial activation and growth, leading to an increase in the production of matrix metalloproteinases (MMPs), especially MMP-9. This study aimed to determine whether the newly developed zinc hyaluronate (Zn-HA) is more effective than Na-HA in inhibiting the growth of synoviocytes or production and activity of MMPs in rheumatoid synoviocytes. Our results showed that Zn-HA inhibited synoviocyte growth, MMP-9 protein production, and MMP-9 mRNA expression, whereas Na-HA exerted only a slight inhibitory effect on these parameters. Moreover, Zn-HA induced synoviocyte apoptosis, whereas Na-HA did not. These results suggest that Zn-HA retards synoviocyte growth by inducing apoptosis following a decrease in the production of MMP-9 and mRNA. Therefore, it is suggested that Zn-HA can suppress arthritis more efficiently than Na-HA.Keywords: synoviocyte, apoptosis, sodium hyaluronate, zinc hyaluronate, rheumatoid arthritis, MMP-9
format	article
author	Seiji Saito Keisei Maekawa Shigeru Kotake
author_facet	Seiji Saito Keisei Maekawa Shigeru Kotake
author_sort	Seiji Saito
title	Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity
title_short	Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity
title_full	Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity
title_fullStr	Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity
title_full_unstemmed	Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity
title_sort	inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/d9e3084f9bd74caba0437ca97f4471e9
work_keys_str_mv	AT seijisaito inhibitoryeffectsofzinchyaluronateonsynoviocytegrowthandmatrixmetalloproteinase9activity AT keiseimaekawa inhibitoryeffectsofzinchyaluronateonsynoviocytegrowthandmatrixmetalloproteinase9activity AT shigerukotake inhibitoryeffectsofzinchyaluronateonsynoviocytegrowthandmatrixmetalloproteinase9activity
_version_	1718403467661279232

Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity

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