Multivalent nanosystems: targeting monocytes/macrophages

Rémy Poupot, Cécile Goursat, Séverine Fruchon INSERM, U1043, CNRS, U5282, Université de Toulouse, UPS; Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France Abstract: Among all the cellular partners involved in inflammatory processes, monocyte...

Full description

Saved in:

Bibliographic Details
Main Authors:	Poupot R, Goursat C, Fruchon S
Format:	article
Language:	EN
Published:	Dove Medical Press 2018
Subjects:	Multivalency Nanosystems Monocytes/Macrophages Inflammatory diseases Medicine (General) R5-920
Online Access:	https://doaj.org/article/d9e50c7b919d433a91d2663242900bef
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:d9e50c7b919d433a91d2663242900bef
record_format	dspace
spelling	oai:doaj.org-article:d9e50c7b919d433a91d2663242900bef2021-12-02T07:56:33ZMultivalent nanosystems: targeting monocytes/macrophages1178-2013https://doaj.org/article/d9e50c7b919d433a91d2663242900bef2018-09-01T00:00:00Zhttps://www.dovepress.com/multivalent-nanosystems-targeting-monocytesmacrophages-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rémy Poupot, Cécile Goursat, Séverine Fruchon INSERM, U1043, CNRS, U5282, Université de Toulouse, UPS; Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France Abstract: Among all the cellular partners involved in inflammatory processes, monocytes and macrophages are the master regulators of inflammation. They are found in almost all the tissues and are nearly the only cells capable of performing each step of inflammation. Consequently, they stand as major relevant therapeutic targets to treat inflammatory disorders and diseases. The physiological phagocytic activity of macrophages prompts them to detect, to recognize, and eventually to engulf any nanosystem cruising in their neighborhood. Interestingly, nanosystems can be rationally engineered to afford multivalent, and multifunctional if needed, entities with multiplexed and/or reinforced biological activities. Indeed, engineered nanosystems bearing moieties specifically targeting macrophages, and loaded with or bound to drugs are promising candidates to modulate, or even eradicate, deleterious macrophages in vivo. In this review we highlight recent articles and concepts of multivalent nanosystems targeting monocytes and macrophages to treat inflammatory disorders. Keywords: multivalency, nanosystems, monocytes/macrophages, inflammatory diseasesPoupot RGoursat CFruchon SDove Medical PressarticleMultivalencyNanosystemsMonocytes/MacrophagesInflammatory diseasesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5511-5521 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multivalency Nanosystems Monocytes/Macrophages Inflammatory diseases Medicine (General) R5-920
spellingShingle	Multivalency Nanosystems Monocytes/Macrophages Inflammatory diseases Medicine (General) R5-920 Poupot R Goursat C Fruchon S Multivalent nanosystems: targeting monocytes/macrophages
description	Rémy Poupot, Cécile Goursat, Séverine Fruchon INSERM, U1043, CNRS, U5282, Université de Toulouse, UPS; Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France Abstract: Among all the cellular partners involved in inflammatory processes, monocytes and macrophages are the master regulators of inflammation. They are found in almost all the tissues and are nearly the only cells capable of performing each step of inflammation. Consequently, they stand as major relevant therapeutic targets to treat inflammatory disorders and diseases. The physiological phagocytic activity of macrophages prompts them to detect, to recognize, and eventually to engulf any nanosystem cruising in their neighborhood. Interestingly, nanosystems can be rationally engineered to afford multivalent, and multifunctional if needed, entities with multiplexed and/or reinforced biological activities. Indeed, engineered nanosystems bearing moieties specifically targeting macrophages, and loaded with or bound to drugs are promising candidates to modulate, or even eradicate, deleterious macrophages in vivo. In this review we highlight recent articles and concepts of multivalent nanosystems targeting monocytes and macrophages to treat inflammatory disorders. Keywords: multivalency, nanosystems, monocytes/macrophages, inflammatory diseases
format	article
author	Poupot R Goursat C Fruchon S
author_facet	Poupot R Goursat C Fruchon S
author_sort	Poupot R
title	Multivalent nanosystems: targeting monocytes/macrophages
title_short	Multivalent nanosystems: targeting monocytes/macrophages
title_full	Multivalent nanosystems: targeting monocytes/macrophages
title_fullStr	Multivalent nanosystems: targeting monocytes/macrophages
title_full_unstemmed	Multivalent nanosystems: targeting monocytes/macrophages
title_sort	multivalent nanosystems: targeting monocytes/macrophages
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d9e50c7b919d433a91d2663242900bef
work_keys_str_mv	AT poupotr multivalentnanosystemstargetingmonocytesmacrophages AT goursatc multivalentnanosystemstargetingmonocytesmacrophages AT fruchons multivalentnanosystemstargetingmonocytesmacrophages
_version_	1718399132083683328

Multivalent nanosystems: targeting monocytes/macrophages

Similar Items