Oncogenic role of MiR-130a in oral squamous cell carcinoma

Abstract Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to the pathogenesis of oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests the involvement of microRNAs (miRNAs) in oral carcinogenesis by acting as tumor suppressors or oncogenes. TSC1, as a compo...

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Autores principales:	Karthik Mallela, Swamy Shivananda, Kodaganur S. Gopinath, Arun Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9e9a99e84eb4b9990a53214d53270f4
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spelling	oai:doaj.org-article:d9e9a99e84eb4b9990a53214d53270f42021-12-02T14:21:11ZOncogenic role of MiR-130a in oral squamous cell carcinoma10.1038/s41598-021-87388-42045-2322https://doaj.org/article/d9e9a99e84eb4b9990a53214d53270f42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87388-4https://doaj.org/toc/2045-2322Abstract Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to the pathogenesis of oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests the involvement of microRNAs (miRNAs) in oral carcinogenesis by acting as tumor suppressors or oncogenes. TSC1, as a component of the above pathway, regulates several cellular functions such as cell proliferation, apoptosis, migration and invasion. Downregulation of TSC1 is reported in oral as well as several other cancers and is associated with an unfavourable clinical outcome in patients. Here we show that oncogenic miR-130a binds to the 3′UTR of TSC1 and represses its expression. MiR-130a-mediated repression of TSC1 increases cell proliferation, anchorage independent growth and invasion of OSCC cells, which is dependent on the presence of the 3′UTR in TSC1. We observe an inverse correlation between the expression levels of miR-130a and TSC1 in OSCC samples, suggesting that their interaction is physiologically relevant. Delivery of antagomiR-130a to OSCC cells results in a significant decrease in xenograft size. Taken together, the findings of the study indicate that miR-130a-mediated TSC1 downregulation is not only a novel mechanism in OSCC, but also the restoration of TSC1 levels by antagomiR-130a may be a potential therapeutic strategy for the treatment of OSCC.Karthik MallelaSwamy ShivanandaKodaganur S. GopinathArun KumarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karthik Mallela Swamy Shivananda Kodaganur S. Gopinath Arun Kumar Oncogenic role of MiR-130a in oral squamous cell carcinoma
description	Abstract Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to the pathogenesis of oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests the involvement of microRNAs (miRNAs) in oral carcinogenesis by acting as tumor suppressors or oncogenes. TSC1, as a component of the above pathway, regulates several cellular functions such as cell proliferation, apoptosis, migration and invasion. Downregulation of TSC1 is reported in oral as well as several other cancers and is associated with an unfavourable clinical outcome in patients. Here we show that oncogenic miR-130a binds to the 3′UTR of TSC1 and represses its expression. MiR-130a-mediated repression of TSC1 increases cell proliferation, anchorage independent growth and invasion of OSCC cells, which is dependent on the presence of the 3′UTR in TSC1. We observe an inverse correlation between the expression levels of miR-130a and TSC1 in OSCC samples, suggesting that their interaction is physiologically relevant. Delivery of antagomiR-130a to OSCC cells results in a significant decrease in xenograft size. Taken together, the findings of the study indicate that miR-130a-mediated TSC1 downregulation is not only a novel mechanism in OSCC, but also the restoration of TSC1 levels by antagomiR-130a may be a potential therapeutic strategy for the treatment of OSCC.
format	article
author	Karthik Mallela Swamy Shivananda Kodaganur S. Gopinath Arun Kumar
author_facet	Karthik Mallela Swamy Shivananda Kodaganur S. Gopinath Arun Kumar
author_sort	Karthik Mallela
title	Oncogenic role of MiR-130a in oral squamous cell carcinoma
title_short	Oncogenic role of MiR-130a in oral squamous cell carcinoma
title_full	Oncogenic role of MiR-130a in oral squamous cell carcinoma
title_fullStr	Oncogenic role of MiR-130a in oral squamous cell carcinoma
title_full_unstemmed	Oncogenic role of MiR-130a in oral squamous cell carcinoma
title_sort	oncogenic role of mir-130a in oral squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d9e9a99e84eb4b9990a53214d53270f4
work_keys_str_mv	AT karthikmallela oncogenicroleofmir130ainoralsquamouscellcarcinoma AT swamyshivananda oncogenicroleofmir130ainoralsquamouscellcarcinoma AT kodaganursgopinath oncogenicroleofmir130ainoralsquamouscellcarcinoma AT arunkumar oncogenicroleofmir130ainoralsquamouscellcarcinoma
_version_	1718391577444876288

Oncogenic role of MiR-130a in oral squamous cell carcinoma

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