Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study

Abstract Obesity has been well studied in relation to breast cancer survival. However, the associations of post-diagnosis obesity and late outcomes (≥5 years after diagnosis) have been much less studied. A total of 4062 5-year disease-free patients were recruited from the Shanghai Breast Cancer Surv...

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Autores principales:	Minlu Zhang, Hui Cai, Pingping Bao, Wanghong Xu, Guoyou Qin, Xiao Ou Shu, Ying Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9e9ba4317d8419d8f461c54f4dc55fd
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spelling	oai:doaj.org-article:d9e9ba4317d8419d8f461c54f4dc55fd2021-12-02T11:40:22ZBody mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study10.1038/s41598-017-07320-72045-2322https://doaj.org/article/d9e9ba4317d8419d8f461c54f4dc55fd2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07320-7https://doaj.org/toc/2045-2322Abstract Obesity has been well studied in relation to breast cancer survival. However, the associations of post-diagnosis obesity and late outcomes (≥5 years after diagnosis) have been much less studied. A total of 4062 5-year disease-free patients were recruited from the Shanghai Breast Cancer Survival Study, a longitudinal study of patients diagnosed during 2002-2006. Cox proportional hazard model with restricted cubic spline were used to evaluate the potential non-linear associations of post-diagnosis body mass index (BMI) and waist-to-hip ratio (WHR) with late all-cause mortality and late recurrence. While no significant association was observed for post-diagnosis BMI or WHR with late recurrence; a U-shaped association was observed for the two measures with late all-cause death. Women with BMI of 25.0 kg/m2 or WHR of 0.83 were at the lowest risk of late all-cause mortality, whereas those with BMI beyond the range of 22.1–28.7 kg/m2 or WHR beyond the range of 0.81–0.86 had a higher risk. ER, stage or menopausal status did not modify the effect of post-diagnosis BMI or WHR on the outcomes. In conclusion, post-diagnosis BMI and WHR, as indicators of overall and central obesity respectively, were associated with late all-cause mortality in U-shaped pattern among long-term breast cancer survivors.Minlu ZhangHui CaiPingping BaoWanghong XuGuoyou QinXiao Ou ShuYing ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Minlu Zhang Hui Cai Pingping Bao Wanghong Xu Guoyou Qin Xiao Ou Shu Ying Zheng Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study
description	Abstract Obesity has been well studied in relation to breast cancer survival. However, the associations of post-diagnosis obesity and late outcomes (≥5 years after diagnosis) have been much less studied. A total of 4062 5-year disease-free patients were recruited from the Shanghai Breast Cancer Survival Study, a longitudinal study of patients diagnosed during 2002-2006. Cox proportional hazard model with restricted cubic spline were used to evaluate the potential non-linear associations of post-diagnosis body mass index (BMI) and waist-to-hip ratio (WHR) with late all-cause mortality and late recurrence. While no significant association was observed for post-diagnosis BMI or WHR with late recurrence; a U-shaped association was observed for the two measures with late all-cause death. Women with BMI of 25.0 kg/m2 or WHR of 0.83 were at the lowest risk of late all-cause mortality, whereas those with BMI beyond the range of 22.1–28.7 kg/m2 or WHR beyond the range of 0.81–0.86 had a higher risk. ER, stage or menopausal status did not modify the effect of post-diagnosis BMI or WHR on the outcomes. In conclusion, post-diagnosis BMI and WHR, as indicators of overall and central obesity respectively, were associated with late all-cause mortality in U-shaped pattern among long-term breast cancer survivors.
format	article
author	Minlu Zhang Hui Cai Pingping Bao Wanghong Xu Guoyou Qin Xiao Ou Shu Ying Zheng
author_facet	Minlu Zhang Hui Cai Pingping Bao Wanghong Xu Guoyou Qin Xiao Ou Shu Ying Zheng
author_sort	Minlu Zhang
title	Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study
title_short	Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study
title_full	Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study
title_fullStr	Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study
title_full_unstemmed	Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study
title_sort	body mass index, waist-to-hip ratio and late outcomes: a report from the shanghai breast cancer survival study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9e9ba4317d8419d8f461c54f4dc55fd
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Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study

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