Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane

High levels of urea and creatinine in the blood are a sign of decreased kidney function. To remove these substances from the blood, hemodialysis which utilizes membranes could be used. In this study, a molecularly imprinted membrane (MIM) was synthesized for the selective transport of urea. The synt...

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Autores principales:	Djunaidi Muhammad Cholid, Febriola Nabilah Anindita, Haris Abdul
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	polyeugenoxy acetate urea molecularly imprinted membrane selectivity Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d9ed7f91a77d4e11baf030c7bbd60afb
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spelling	oai:doaj.org-article:d9ed7f91a77d4e11baf030c7bbd60afb2021-12-05T14:10:44ZMolecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane2391-542010.1515/chem-2021-0069https://doaj.org/article/d9ed7f91a77d4e11baf030c7bbd60afb2021-07-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0069https://doaj.org/toc/2391-5420High levels of urea and creatinine in the blood are a sign of decreased kidney function. To remove these substances from the blood, hemodialysis which utilizes membranes could be used. In this study, a molecularly imprinted membrane (MIM) was synthesized for the selective transport of urea. The synthesis is initiated with the polymerization of eugenol into polyeugenol and then into polyeugenoxy acetate (PA). The PA is then contacted with urea and then used as the functional polymer in the synthesis of MIM with polysulfone as the membrane base, and polyethylene glycol as the cross-linking agent. The result was later analyzed with FTIR and SEM-EDX. The membrane is then used in the transport of urea, creatinine, and vitamin B12 and then compared with the non-imprinted membrane (NIM) performance. By using UV-Vis spectrophotometry, the results showed that the membrane with 10 h heating variation is able to transport more urea and is more selective than NIM; this proves that the urea template on the MIM enables it to recognize urea molecules better than creatinine and vitamin B12. The order of transport from the best results is urea > creatinine > vitamin B12.Djunaidi Muhammad CholidFebriola Nabilah AninditaHaris AbdulDe Gruyterarticlepolyeugenoxy acetateureamolecularly imprinted membraneselectivityChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 806-817 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyeugenoxy acetate urea molecularly imprinted membrane selectivity Chemistry QD1-999
spellingShingle	polyeugenoxy acetate urea molecularly imprinted membrane selectivity Chemistry QD1-999 Djunaidi Muhammad Cholid Febriola Nabilah Anindita Haris Abdul Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane
description	High levels of urea and creatinine in the blood are a sign of decreased kidney function. To remove these substances from the blood, hemodialysis which utilizes membranes could be used. In this study, a molecularly imprinted membrane (MIM) was synthesized for the selective transport of urea. The synthesis is initiated with the polymerization of eugenol into polyeugenol and then into polyeugenoxy acetate (PA). The PA is then contacted with urea and then used as the functional polymer in the synthesis of MIM with polysulfone as the membrane base, and polyethylene glycol as the cross-linking agent. The result was later analyzed with FTIR and SEM-EDX. The membrane is then used in the transport of urea, creatinine, and vitamin B12 and then compared with the non-imprinted membrane (NIM) performance. By using UV-Vis spectrophotometry, the results showed that the membrane with 10 h heating variation is able to transport more urea and is more selective than NIM; this proves that the urea template on the MIM enables it to recognize urea molecules better than creatinine and vitamin B12. The order of transport from the best results is urea > creatinine > vitamin B12.
format	article
author	Djunaidi Muhammad Cholid Febriola Nabilah Anindita Haris Abdul
author_facet	Djunaidi Muhammad Cholid Febriola Nabilah Anindita Haris Abdul
author_sort	Djunaidi Muhammad Cholid
title	Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane
title_short	Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane
title_full	Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane
title_fullStr	Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane
title_full_unstemmed	Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane
title_sort	molecularly imprinted membrane for transport of urea, creatinine, and vitamin b12 as a hemodialysis candidate membrane
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/d9ed7f91a77d4e11baf030c7bbd60afb
work_keys_str_mv	AT djunaidimuhammadcholid molecularlyimprintedmembranefortransportofureacreatinineandvitaminb12asahemodialysiscandidatemembrane AT febriolanabilahanindita molecularlyimprintedmembranefortransportofureacreatinineandvitaminb12asahemodialysiscandidatemembrane AT harisabdul molecularlyimprintedmembranefortransportofureacreatinineandvitaminb12asahemodialysiscandidatemembrane
_version_	1718371811857530880

Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane

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