Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies

Acetylcholine (ACh) in the striatum is involved in mediating action flexibility. Here the authors show that midbrain cholinergic nuclei provide a new source of Ach in the striatum, form excitatory synapses with striatal cholinergic interneurons (CIN) and contribute to instrumental learning.

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Autores principales:	Daniel Dautan, Icnelia Huerta-Ocampo, Nadine K. Gut, Miguel Valencia, Krishnakanth Kondabolu, Yuwoong Kim, Todor V. Gerdjikov, Juan Mena-Segovia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9ef9606aeda407eb4073590fbf4e724
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spelling	oai:doaj.org-article:d9ef9606aeda407eb4073590fbf4e7242021-12-02T15:39:12ZCholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies10.1038/s41467-020-15514-32041-1723https://doaj.org/article/d9ef9606aeda407eb4073590fbf4e7242020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15514-3https://doaj.org/toc/2041-1723Acetylcholine (ACh) in the striatum is involved in mediating action flexibility. Here the authors show that midbrain cholinergic nuclei provide a new source of Ach in the striatum, form excitatory synapses with striatal cholinergic interneurons (CIN) and contribute to instrumental learning.Daniel DautanIcnelia Huerta-OcampoNadine K. GutMiguel ValenciaKrishnakanth KondaboluYuwoong KimTodor V. GerdjikovJuan Mena-SegoviaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Dautan Icnelia Huerta-Ocampo Nadine K. Gut Miguel Valencia Krishnakanth Kondabolu Yuwoong Kim Todor V. Gerdjikov Juan Mena-Segovia Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
description	Acetylcholine (ACh) in the striatum is involved in mediating action flexibility. Here the authors show that midbrain cholinergic nuclei provide a new source of Ach in the striatum, form excitatory synapses with striatal cholinergic interneurons (CIN) and contribute to instrumental learning.
format	article
author	Daniel Dautan Icnelia Huerta-Ocampo Nadine K. Gut Miguel Valencia Krishnakanth Kondabolu Yuwoong Kim Todor V. Gerdjikov Juan Mena-Segovia
author_facet	Daniel Dautan Icnelia Huerta-Ocampo Nadine K. Gut Miguel Valencia Krishnakanth Kondabolu Yuwoong Kim Todor V. Gerdjikov Juan Mena-Segovia
author_sort	Daniel Dautan
title	Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
title_short	Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
title_full	Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
title_fullStr	Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
title_full_unstemmed	Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
title_sort	cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d9ef9606aeda407eb4073590fbf4e724
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Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies

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