Comparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients

BACKGROUND AND OBJECTIVE: Thalassemia is the most common hereditary disease. Hypersplenism and splenomegaly occur in thalassemic patients due to the hereditary defect in globin chain of hemoglobin molecule and extramedullary hematopoiesis that results in more destruction in red blood cells. Therefor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	AA Darzi, A Tamaddoni, MS Ramezani, L Ramezani, F Gharghabi, N Soleymanpour
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	thalassemia major thalassemia intermediate splenectomy blood transfusion portal vein Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d9f25c1454934af5b06acb0f629503fa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d9f25c1454934af5b06acb0f629503fa
record_format	dspace
spelling	oai:doaj.org-article:d9f25c1454934af5b06acb0f629503fa2021-11-10T08:53:19ZComparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients1561-41072251-7170https://doaj.org/article/d9f25c1454934af5b06acb0f629503fa2012-07-01T00:00:00Zhttp://jbums.org/article-1-4148-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Thalassemia is the most common hereditary disease. Hypersplenism and splenomegaly occur in thalassemic patients due to the hereditary defect in globin chain of hemoglobin molecule and extramedullary hematopoiesis that results in more destruction in red blood cells. Therefore, these patients need to splenectomy to reduce recurrent blood transfusion and its complications. The aim of this study was to compare the need of transfusion and adverse effects before and after splenectomy in beta-thalassemic patients referred to Yahyanejad hospital (Babol, Iran).METHODS: This cross sectional study was performed on 63 splenectomized thalassemic patients who referred to Yahyanejad hospital in Babol during 8 years. Demographic information, kind of thalassemia, clinical symptoms, spleen size, number of transfusions, and platelet and red blood cell count were evaluated before and after splenectomy in these patients.FINDINGS: In this study, 37 (58.7%) out of the 63 cases had thalassemia major and 26 cases (41.2%) had thalassemia intermedia. Eleven, 21, 9 and 17 cases had abdominal pain, anorexia, fever and gall stone, respectively. These patients had undergone cholecystectomy simultaneously. Six cases had portal vein thrombosis and 5 patients had infectious complications in long time post splenectomy. Mean operation time and mean hospital stay was 2.70±0.73 and 6.26±2.14. Mean white blood cell count, hemoglobin level, platelets and red blood cells (RBCs) count were raised significantly after splenectomy (p<0.05). Mean transfusion was reduced (p<0.05). We found 26 hepatitis, 14 haemosiderosis, 1 cirrhosis and 6 portal vein thrombosis (PVT) cases on pathology report of liver biopsy.CONCLUSION: Splenectomy reduces blood transfusion times and its complications in thalassemic patients, therefore splenectomy recommends in patients with indications for surgery.AA Darzi,A TamaddoniMS RamezaniL RamezaniF Gharghabi,N SoleymanpourBabol University of Medical Sciencesarticlethalassemia majorthalassemia intermediatesplenectomyblood transfusionportal veinMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 4, Pp 83-89 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	thalassemia major thalassemia intermediate splenectomy blood transfusion portal vein Medicine R Medicine (General) R5-920
spellingShingle	thalassemia major thalassemia intermediate splenectomy blood transfusion portal vein Medicine R Medicine (General) R5-920 AA Darzi, A Tamaddoni MS Ramezani L Ramezani F Gharghabi, N Soleymanpour Comparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients
description	BACKGROUND AND OBJECTIVE: Thalassemia is the most common hereditary disease. Hypersplenism and splenomegaly occur in thalassemic patients due to the hereditary defect in globin chain of hemoglobin molecule and extramedullary hematopoiesis that results in more destruction in red blood cells. Therefore, these patients need to splenectomy to reduce recurrent blood transfusion and its complications. The aim of this study was to compare the need of transfusion and adverse effects before and after splenectomy in beta-thalassemic patients referred to Yahyanejad hospital (Babol, Iran).METHODS: This cross sectional study was performed on 63 splenectomized thalassemic patients who referred to Yahyanejad hospital in Babol during 8 years. Demographic information, kind of thalassemia, clinical symptoms, spleen size, number of transfusions, and platelet and red blood cell count were evaluated before and after splenectomy in these patients.FINDINGS: In this study, 37 (58.7%) out of the 63 cases had thalassemia major and 26 cases (41.2%) had thalassemia intermedia. Eleven, 21, 9 and 17 cases had abdominal pain, anorexia, fever and gall stone, respectively. These patients had undergone cholecystectomy simultaneously. Six cases had portal vein thrombosis and 5 patients had infectious complications in long time post splenectomy. Mean operation time and mean hospital stay was 2.70±0.73 and 6.26±2.14. Mean white blood cell count, hemoglobin level, platelets and red blood cells (RBCs) count were raised significantly after splenectomy (p<0.05). Mean transfusion was reduced (p<0.05). We found 26 hepatitis, 14 haemosiderosis, 1 cirrhosis and 6 portal vein thrombosis (PVT) cases on pathology report of liver biopsy.CONCLUSION: Splenectomy reduces blood transfusion times and its complications in thalassemic patients, therefore splenectomy recommends in patients with indications for surgery.
format	article
author	AA Darzi, A Tamaddoni MS Ramezani L Ramezani F Gharghabi, N Soleymanpour
author_facet	AA Darzi, A Tamaddoni MS Ramezani L Ramezani F Gharghabi, N Soleymanpour
author_sort	AA Darzi,
title	Comparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients
title_short	Comparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients
title_full	Comparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients
title_fullStr	Comparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients
title_full_unstemmed	Comparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients
title_sort	comparison of need of transfusion and adverse effects before and after splenectomy in beta-thalassemic patients
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/d9f25c1454934af5b06acb0f629503fa
work_keys_str_mv	AT aadarzi comparisonofneedoftransfusionandadverseeffectsbeforeandaftersplenectomyinbetathalassemicpatients AT atamaddoni comparisonofneedoftransfusionandadverseeffectsbeforeandaftersplenectomyinbetathalassemicpatients AT msramezani comparisonofneedoftransfusionandadverseeffectsbeforeandaftersplenectomyinbetathalassemicpatients AT lramezani comparisonofneedoftransfusionandadverseeffectsbeforeandaftersplenectomyinbetathalassemicpatients AT fgharghabi comparisonofneedoftransfusionandadverseeffectsbeforeandaftersplenectomyinbetathalassemicpatients AT nsoleymanpour comparisonofneedoftransfusionandadverseeffectsbeforeandaftersplenectomyinbetathalassemicpatients
_version_	1718440421760172032

Comparison of Need of Transfusion and Adverse Effects before and after Splenectomy in Beta-Thalassemic Patients

Ejemplares similares