A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

A limited percentage of patients with non-small cell lung cancer respond to immunotherapy. Here the authors show that HEI3090, a chemical positive modulator of the purinergic P2RX7 receptor, promotes IL-18 mediated anti-tumor immune responses and sensitizes lung cancer to anti-PD-1 therapy in precli...

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Autores principales:	Laetitia Douguet, Serena Janho dit Hreich, Jonathan Benzaquen, Laetitia Seguin, Thierry Juhel, Xavier Dezitter, Christophe Duranton, Bernhard Ryffel, Jean Kanellopoulos, Cecile Delarasse, Nicolas Renault, Christophe Furman, Germain Homerin, Chloé Féral, Julien Cherfils-Vicini, Régis Millet, Sahil Adriouch, Alina Ghinet, Paul Hofman, Valérie Vouret-Craviari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9f2cc20554a4d0e92405e7e329a31b4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d9f2cc20554a4d0e92405e7e329a31b42021-12-02T14:16:13ZA small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy10.1038/s41467-021-20912-22041-1723https://doaj.org/article/d9f2cc20554a4d0e92405e7e329a31b42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20912-2https://doaj.org/toc/2041-1723A limited percentage of patients with non-small cell lung cancer respond to immunotherapy. Here the authors show that HEI3090, a chemical positive modulator of the purinergic P2RX7 receptor, promotes IL-18 mediated anti-tumor immune responses and sensitizes lung cancer to anti-PD-1 therapy in preclinical models.Laetitia DouguetSerena Janho dit HreichJonathan BenzaquenLaetitia SeguinThierry JuhelXavier DezitterChristophe DurantonBernhard RyffelJean KanellopoulosCecile DelarasseNicolas RenaultChristophe FurmanGermain HomerinChloé FéralJulien Cherfils-ViciniRégis MilletSahil AdriouchAlina GhinetPaul HofmanValérie Vouret-CraviariNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laetitia Douguet Serena Janho dit Hreich Jonathan Benzaquen Laetitia Seguin Thierry Juhel Xavier Dezitter Christophe Duranton Bernhard Ryffel Jean Kanellopoulos Cecile Delarasse Nicolas Renault Christophe Furman Germain Homerin Chloé Féral Julien Cherfils-Vicini Régis Millet Sahil Adriouch Alina Ghinet Paul Hofman Valérie Vouret-Craviari A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
description	A limited percentage of patients with non-small cell lung cancer respond to immunotherapy. Here the authors show that HEI3090, a chemical positive modulator of the purinergic P2RX7 receptor, promotes IL-18 mediated anti-tumor immune responses and sensitizes lung cancer to anti-PD-1 therapy in preclinical models.
format	article
author	Laetitia Douguet Serena Janho dit Hreich Jonathan Benzaquen Laetitia Seguin Thierry Juhel Xavier Dezitter Christophe Duranton Bernhard Ryffel Jean Kanellopoulos Cecile Delarasse Nicolas Renault Christophe Furman Germain Homerin Chloé Féral Julien Cherfils-Vicini Régis Millet Sahil Adriouch Alina Ghinet Paul Hofman Valérie Vouret-Craviari
author_facet	Laetitia Douguet Serena Janho dit Hreich Jonathan Benzaquen Laetitia Seguin Thierry Juhel Xavier Dezitter Christophe Duranton Bernhard Ryffel Jean Kanellopoulos Cecile Delarasse Nicolas Renault Christophe Furman Germain Homerin Chloé Féral Julien Cherfils-Vicini Régis Millet Sahil Adriouch Alina Ghinet Paul Hofman Valérie Vouret-Craviari
author_sort	Laetitia Douguet
title	A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
title_short	A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
title_full	A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
title_fullStr	A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
title_full_unstemmed	A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
title_sort	small-molecule p2rx7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d9f2cc20554a4d0e92405e7e329a31b4
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A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

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