Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus

Detailed characterization of large-scale hemodynamic responses linked to specific neural activity remains to be elucidated at the single-vessel level across the subcentimeter scale hippocampal vasculature in vivo. Here, authors use a novel multi-modal fMRI platform to characterize distinct spatiotem...

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Autores principales:	Xuming Chen, Filip Sobczak, Yi Chen, Yuanyuan Jiang, Chunqi Qian, Zuneng Lu, Cenk Ayata, Nikos K. Logothetis, Xin Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9f4bff0de2c4e8aaf801a87e8442fb5
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spelling	oai:doaj.org-article:d9f4bff0de2c4e8aaf801a87e8442fb52021-12-02T14:39:42ZMapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus10.1038/s41467-019-12850-x2041-1723https://doaj.org/article/d9f4bff0de2c4e8aaf801a87e8442fb52019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12850-xhttps://doaj.org/toc/2041-1723Detailed characterization of large-scale hemodynamic responses linked to specific neural activity remains to be elucidated at the single-vessel level across the subcentimeter scale hippocampal vasculature in vivo. Here, authors use a novel multi-modal fMRI platform to characterize distinct spatiotemporal patterns of hippocampal hemodynamic responses that were correlated to the optogenetically evoked Ca2+ events and to further demonstrate the significantly reduced neurovascular coupling efficiency upon spreading depression-like Ca2+ events.Xuming ChenFilip SobczakYi ChenYuanyuan JiangChunqi QianZuneng LuCenk AyataNikos K. LogothetisXin YuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuming Chen Filip Sobczak Yi Chen Yuanyuan Jiang Chunqi Qian Zuneng Lu Cenk Ayata Nikos K. Logothetis Xin Yu Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus
description	Detailed characterization of large-scale hemodynamic responses linked to specific neural activity remains to be elucidated at the single-vessel level across the subcentimeter scale hippocampal vasculature in vivo. Here, authors use a novel multi-modal fMRI platform to characterize distinct spatiotemporal patterns of hippocampal hemodynamic responses that were correlated to the optogenetically evoked Ca2+ events and to further demonstrate the significantly reduced neurovascular coupling efficiency upon spreading depression-like Ca2+ events.
format	article
author	Xuming Chen Filip Sobczak Yi Chen Yuanyuan Jiang Chunqi Qian Zuneng Lu Cenk Ayata Nikos K. Logothetis Xin Yu
author_facet	Xuming Chen Filip Sobczak Yi Chen Yuanyuan Jiang Chunqi Qian Zuneng Lu Cenk Ayata Nikos K. Logothetis Xin Yu
author_sort	Xuming Chen
title	Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus
title_short	Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus
title_full	Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus
title_fullStr	Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus
title_full_unstemmed	Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus
title_sort	mapping optogenetically-driven single-vessel fmri with concurrent neuronal calcium recordings in the rat hippocampus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d9f4bff0de2c4e8aaf801a87e8442fb5
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Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus

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