Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

mTORC1 regulates cellular growth from the lysosome, but how changes in the organisation of the lysosomal system affect mTORC1 signalling is poorly understood. Here the authors show that amino acid-dependent Rap1-mediated changes in lysosomal abundance determine overall signalling output of mTORC1.

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Autores principales:	Anders P. Mutvei, Michal J. Nagiec, Jens C. Hamann, Sang Gyun Kim, C. Theresa Vincent, John Blenis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9f515d0941c4033977289572a61fdd5
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spelling	oai:doaj.org-article:d9f515d0941c4033977289572a61fdd52021-12-02T17:33:13ZRap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability10.1038/s41467-020-15156-52041-1723https://doaj.org/article/d9f515d0941c4033977289572a61fdd52020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15156-5https://doaj.org/toc/2041-1723mTORC1 regulates cellular growth from the lysosome, but how changes in the organisation of the lysosomal system affect mTORC1 signalling is poorly understood. Here the authors show that amino acid-dependent Rap1-mediated changes in lysosomal abundance determine overall signalling output of mTORC1.Anders P. MutveiMichal J. NagiecJens C. HamannSang Gyun KimC. Theresa VincentJohn BlenisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anders P. Mutvei Michal J. Nagiec Jens C. Hamann Sang Gyun Kim C. Theresa Vincent John Blenis Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
description	mTORC1 regulates cellular growth from the lysosome, but how changes in the organisation of the lysosomal system affect mTORC1 signalling is poorly understood. Here the authors show that amino acid-dependent Rap1-mediated changes in lysosomal abundance determine overall signalling output of mTORC1.
format	article
author	Anders P. Mutvei Michal J. Nagiec Jens C. Hamann Sang Gyun Kim C. Theresa Vincent John Blenis
author_facet	Anders P. Mutvei Michal J. Nagiec Jens C. Hamann Sang Gyun Kim C. Theresa Vincent John Blenis
author_sort	Anders P. Mutvei
title	Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
title_short	Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
title_full	Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
title_fullStr	Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
title_full_unstemmed	Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
title_sort	rap1-gtpases control mtorc1 activity by coordinating lysosome organization with amino acid availability
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d9f515d0941c4033977289572a61fdd5
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Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

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