Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2

Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2

Abstract An efficient treatment against a COVID-19 disease, caused by the novel coronavirus SARS-CoV-2 (CoV2), remains a challenge. The papain-like protease (PLpro) from the human coronavirus is a protease that plays a critical role in virus replication. Moreover, CoV2 uses this enzyme to modulate t...

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Autores principales: Ewelina Weglarz-Tomczak, Jakub M. Tomczak, Michał Talma, Małgorzata Burda-Grabowska, Mirosław Giurg, Stanley Brul
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d9f5c84dfce444628997569956549aae
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