The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome

Preeclampsia (PE) is a multisystemic disease of pregnancy affecting 2–8% of women worldwide. PE-induced liver disease is a rare but important complication of pregnancy. The pathogenesis of liver dysfunction in PE is poorly understood, but is correlated with dysregulated angiogenic, inflammatory, and...

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Autores principales:	Andrea N. Johnston, Tifini L. Batts, Ingeborg M. Langohr, Cambri Moeller, Chin-Chi Liu, Jennifer L. Sones
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	preeclampsia HELLP syndrome hepatic steatosis BPH/5 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d9fa84946b304af48502fbccc3cb4d6f
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spelling	oai:doaj.org-article:d9fa84946b304af48502fbccc3cb4d6f2021-11-25T16:47:44ZThe BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome10.3390/biology101111792079-7737https://doaj.org/article/d9fa84946b304af48502fbccc3cb4d6f2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1179https://doaj.org/toc/2079-7737Preeclampsia (PE) is a multisystemic disease of pregnancy affecting 2–8% of women worldwide. PE-induced liver disease is a rare but important complication of pregnancy. The pathogenesis of liver dysfunction in PE is poorly understood, but is correlated with dysregulated angiogenic, inflammatory, and hypoxic events in the early phase of placental development. Because BPH/5 mice develop the maternal and fetal hallmarks of PE during pregnancy, we hypothesized that they may also share the clinicopathologic findings of the human PE-associated hemolysis elevated liver transaminases low platelets (HELLP) syndrome. Using this model, we determined that microangiopathic hemolysis, thrombocytopenia, and elevated liver enzymes do not occur in mid to late gestation. Pregnant BPH/5 mice do not develop histologic evidence of hepatic inflammation, but they do have increased microsteatosis scores at preconception and in mid to late gestation that progress to macrosteatosis in a subset of mice in late gestation. The transcriptional upregulation of TNF-α, CXCL-10, and TLR-2 occurs in mid gestation prior to the onset of macrosteatosis. The BPH/5 female mouse is not a model of HELLP syndrome, but may be a model of fatty liver disease associated with pregnancy.Andrea N. JohnstonTifini L. BattsIngeborg M. LangohrCambri MoellerChin-Chi LiuJennifer L. SonesMDPI AGarticlepreeclampsiaHELLP syndromehepatic steatosisBPH/5Biology (General)QH301-705.5ENBiology, Vol 10, Iss 1179, p 1179 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	preeclampsia HELLP syndrome hepatic steatosis BPH/5 Biology (General) QH301-705.5
spellingShingle	preeclampsia HELLP syndrome hepatic steatosis BPH/5 Biology (General) QH301-705.5 Andrea N. Johnston Tifini L. Batts Ingeborg M. Langohr Cambri Moeller Chin-Chi Liu Jennifer L. Sones The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome
description	Preeclampsia (PE) is a multisystemic disease of pregnancy affecting 2–8% of women worldwide. PE-induced liver disease is a rare but important complication of pregnancy. The pathogenesis of liver dysfunction in PE is poorly understood, but is correlated with dysregulated angiogenic, inflammatory, and hypoxic events in the early phase of placental development. Because BPH/5 mice develop the maternal and fetal hallmarks of PE during pregnancy, we hypothesized that they may also share the clinicopathologic findings of the human PE-associated hemolysis elevated liver transaminases low platelets (HELLP) syndrome. Using this model, we determined that microangiopathic hemolysis, thrombocytopenia, and elevated liver enzymes do not occur in mid to late gestation. Pregnant BPH/5 mice do not develop histologic evidence of hepatic inflammation, but they do have increased microsteatosis scores at preconception and in mid to late gestation that progress to macrosteatosis in a subset of mice in late gestation. The transcriptional upregulation of TNF-α, CXCL-10, and TLR-2 occurs in mid gestation prior to the onset of macrosteatosis. The BPH/5 female mouse is not a model of HELLP syndrome, but may be a model of fatty liver disease associated with pregnancy.
format	article
author	Andrea N. Johnston Tifini L. Batts Ingeborg M. Langohr Cambri Moeller Chin-Chi Liu Jennifer L. Sones
author_facet	Andrea N. Johnston Tifini L. Batts Ingeborg M. Langohr Cambri Moeller Chin-Chi Liu Jennifer L. Sones
author_sort	Andrea N. Johnston
title	The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome
title_short	The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome
title_full	The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome
title_fullStr	The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome
title_full_unstemmed	The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome
title_sort	bph/5 mouse model of superimposed preeclampsia is not a model of hellp syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d9fa84946b304af48502fbccc3cb4d6f
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The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome

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