Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Jie Chen, Hao Wang, Wei Long, Xiu Shen, Di Wu, Sha-Sha Song, Yuan-Ming Sun, Pei-Xun Liu, Saijun Fan, Feiyue Fan, Xiao-Dong ZhangTianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People&...

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Autores principales:	Chen J, Wang H, Long W, Shen X, Wu D, Song SS, Sun YM, Liu PX, Fan S, Fan F, Zhang XD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d9fb836f0c104fe3b852e61bcd002128
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spelling	oai:doaj.org-article:d9fb836f0c104fe3b852e61bcd0021282021-12-02T01:07:57ZSex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice1176-91141178-2013https://doaj.org/article/d9fb836f0c104fe3b852e61bcd0021282013-07-01T00:00:00Zhttp://www.dovepress.com/sex-differences-in-the-toxicity-of-polyethylene-glycol-coated-gold-nan-a13577https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jie Chen, Hao Wang, Wei Long, Xiu Shen, Di Wu, Sha-Sha Song, Yuan-Ming Sun, Pei-Xun Liu, Saijun Fan, Feiyue Fan, Xiao-Dong ZhangTianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of ChinaAbstract: Gold nanoparticles have received wide interest in disease diagnosis and therapy, but one of the important issues is their toxicological effects in vivo. Sex differences in the toxicity of gold nanoparticles are not clear. In this work, body weight, organ weight, hematology, and biochemistry were used to evaluate sex differences in immune response and liver and kidney damage. Pathology was used to observe the general toxicity of reproductive organs. The immune response was influenced significantly in female mice, with obvious changes in spleen and thymus index. Hematology results showed that male mice treated with 22.5 nm gold nanoparticles received more significant infection and inflammation than female mice. Meanwhile, the biochemistry results showed that 4.4 and 22.5 nm gold nanoparticles caused more significant liver damage in male mice than female mice, while 22.5, 29.3, and 36.1 nm gold nanoparticles caused more significant kidney damage in female mice than male mice. No significant toxicological response was found in the reproductive system for female or male mice. It was found that gold nanoparticles caused more serious liver toxicity and infection in male mice than female mice. These findings indicated that sex differences may be one of the important elements for in vivo toxicity of gold nanoparticles.Keywords: sex differences, toxicity, gold nanoparticlesChen JWang HLong WShen XWu DSong SSSun YMLiu PXFan SFan FZhang XDDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2409-2419 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chen J Wang H Long W Shen X Wu D Song SS Sun YM Liu PX Fan S Fan F Zhang XD Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice
description	Jie Chen, Hao Wang, Wei Long, Xiu Shen, Di Wu, Sha-Sha Song, Yuan-Ming Sun, Pei-Xun Liu, Saijun Fan, Feiyue Fan, Xiao-Dong ZhangTianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of ChinaAbstract: Gold nanoparticles have received wide interest in disease diagnosis and therapy, but one of the important issues is their toxicological effects in vivo. Sex differences in the toxicity of gold nanoparticles are not clear. In this work, body weight, organ weight, hematology, and biochemistry were used to evaluate sex differences in immune response and liver and kidney damage. Pathology was used to observe the general toxicity of reproductive organs. The immune response was influenced significantly in female mice, with obvious changes in spleen and thymus index. Hematology results showed that male mice treated with 22.5 nm gold nanoparticles received more significant infection and inflammation than female mice. Meanwhile, the biochemistry results showed that 4.4 and 22.5 nm gold nanoparticles caused more significant liver damage in male mice than female mice, while 22.5, 29.3, and 36.1 nm gold nanoparticles caused more significant kidney damage in female mice than male mice. No significant toxicological response was found in the reproductive system for female or male mice. It was found that gold nanoparticles caused more serious liver toxicity and infection in male mice than female mice. These findings indicated that sex differences may be one of the important elements for in vivo toxicity of gold nanoparticles.Keywords: sex differences, toxicity, gold nanoparticles
format	article
author	Chen J Wang H Long W Shen X Wu D Song SS Sun YM Liu PX Fan S Fan F Zhang XD
author_facet	Chen J Wang H Long W Shen X Wu D Song SS Sun YM Liu PX Fan S Fan F Zhang XD
author_sort	Chen J
title	Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice
title_short	Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice
title_full	Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice
title_fullStr	Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice
title_full_unstemmed	Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice
title_sort	sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d9fb836f0c104fe3b852e61bcd002128
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Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

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