Differential effects of alkaloids on memory in rodents

Abstract Nicotinic acetylcholine receptors (nAChRs) play a critical role in the neuropharmacology of learning and memory. As such, naturally occurring alkaloids that regulate nAChR activity have gained interest for understanding and potentially improving memory function. In this study, we tested the...

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Autores principales:	Patrick M. Callahan, Alvin V. Terry, Manuel C. Peitsch, Julia Hoeng, Kyoko Koshibu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9ffe08222aa45239ce9d05f680373dc
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spelling	oai:doaj.org-article:d9ffe08222aa45239ce9d05f680373dc2021-12-02T16:58:09ZDifferential effects of alkaloids on memory in rodents10.1038/s41598-021-89245-w2045-2322https://doaj.org/article/d9ffe08222aa45239ce9d05f680373dc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89245-whttps://doaj.org/toc/2045-2322Abstract Nicotinic acetylcholine receptors (nAChRs) play a critical role in the neuropharmacology of learning and memory. As such, naturally occurring alkaloids that regulate nAChR activity have gained interest for understanding and potentially improving memory function. In this study, we tested the acute effects of three known nicotinic alkaloids, nicotine, cotinine, and anatabine, in suppressing scopolamine-induced memory deficit in rodents by using two classic memory paradigms, Y-maze and novel object recognition (NOR) in mice and rats, respectively. We found that all compounds were able to suppress scopolamine-induced spatial memory deficit in the Y-maze spontaneous alternation paradigm. However, only nicotine was able to suppress the short-term object memory deficit in NOR, despite the higher doses of cotinine and anatabine used to account for their potential differences in nAChR activity. These results indicate that cotinine and anatabine can uniquely regulate short-term spatial memory, while nicotine seems to have more robust and general role in memory regulation in rodents. Thus, nAChR-activating alkaloids may possess distinct procognitive properties in rodents, depending on the memory types examined.Patrick M. CallahanAlvin V. TerryManuel C. PeitschJulia HoengKyoko KoshibuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrick M. Callahan Alvin V. Terry Manuel C. Peitsch Julia Hoeng Kyoko Koshibu Differential effects of alkaloids on memory in rodents
description	Abstract Nicotinic acetylcholine receptors (nAChRs) play a critical role in the neuropharmacology of learning and memory. As such, naturally occurring alkaloids that regulate nAChR activity have gained interest for understanding and potentially improving memory function. In this study, we tested the acute effects of three known nicotinic alkaloids, nicotine, cotinine, and anatabine, in suppressing scopolamine-induced memory deficit in rodents by using two classic memory paradigms, Y-maze and novel object recognition (NOR) in mice and rats, respectively. We found that all compounds were able to suppress scopolamine-induced spatial memory deficit in the Y-maze spontaneous alternation paradigm. However, only nicotine was able to suppress the short-term object memory deficit in NOR, despite the higher doses of cotinine and anatabine used to account for their potential differences in nAChR activity. These results indicate that cotinine and anatabine can uniquely regulate short-term spatial memory, while nicotine seems to have more robust and general role in memory regulation in rodents. Thus, nAChR-activating alkaloids may possess distinct procognitive properties in rodents, depending on the memory types examined.
format	article
author	Patrick M. Callahan Alvin V. Terry Manuel C. Peitsch Julia Hoeng Kyoko Koshibu
author_facet	Patrick M. Callahan Alvin V. Terry Manuel C. Peitsch Julia Hoeng Kyoko Koshibu
author_sort	Patrick M. Callahan
title	Differential effects of alkaloids on memory in rodents
title_short	Differential effects of alkaloids on memory in rodents
title_full	Differential effects of alkaloids on memory in rodents
title_fullStr	Differential effects of alkaloids on memory in rodents
title_full_unstemmed	Differential effects of alkaloids on memory in rodents
title_sort	differential effects of alkaloids on memory in rodents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d9ffe08222aa45239ce9d05f680373dc
work_keys_str_mv	AT patrickmcallahan differentialeffectsofalkaloidsonmemoryinrodents AT alvinvterry differentialeffectsofalkaloidsonmemoryinrodents AT manuelcpeitsch differentialeffectsofalkaloidsonmemoryinrodents AT juliahoeng differentialeffectsofalkaloidsonmemoryinrodents AT kyokokoshibu differentialeffectsofalkaloidsonmemoryinrodents
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Differential effects of alkaloids on memory in rodents

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