Stimulating Tear Production: Spotlight on Neurostimulation

Michael D Yu,1 Ji Kwan Park,2 Andrea L Kossler1 1Oculoplastic Surgery and Orbital Oncology Service, Byers Eye Institute, Stanford University, Palo Alto, CA, USA; 2Oculofacial Plastic and Orbital Surgery, Indianapolis, IN, USACorrespondence: Andrea L KosslerOculoplastic Surgery and Orbital Oncology S...

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Autores principales:	Yu MD, Park JK, Kossler AL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	oculoplastics ocular surface cornea lacrimal gland dry eye disease tears neurostimulation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/da00489aec2c450d8e59d5409aabe878
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spelling	oai:doaj.org-article:da00489aec2c450d8e59d5409aabe8782021-12-02T17:57:02ZStimulating Tear Production: Spotlight on Neurostimulation1177-5483https://doaj.org/article/da00489aec2c450d8e59d5409aabe8782021-10-01T00:00:00Zhttps://www.dovepress.com/stimulating-tear-production-spotlight-on-neurostimulation-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Michael D Yu,1 Ji Kwan Park,2 Andrea L Kossler1 1Oculoplastic Surgery and Orbital Oncology Service, Byers Eye Institute, Stanford University, Palo Alto, CA, USA; 2Oculofacial Plastic and Orbital Surgery, Indianapolis, IN, USACorrespondence: Andrea L KosslerOculoplastic Surgery and Orbital Oncology Service, Byers Eye Institute, Stanford University, 2452 Watson Ct, Palo Alto, CA 94303, USATel +1 650-724-0105Email akossler@stanford.eduAbstract: Dry eye disease (DED) affects up to one-third of the global population. Traditional therapies, including topical lubricants, have been employed with variable success in the treatment of DED. Recently, neurostimulation of the lacrimal functional unit (LFU) has emerged as a promising alternative therapy for DED. In this review, we describe the neuroanatomical and pathophysiological considerations of DED and the LFU that make neurostimulation a viable therapeutic alternative. We further detail the various neurostimulatory approaches taken thus far—from implanted stimulators to external devices to chemical neurostimulation. Existing studies reveal the strengths of the neurostimulatory approach in increasing tear volume and improving dry eye symptoms, but further studies are needed to elucidate its true potential in treatment of DED.Keywords: oculoplastics, ocular surface, cornea, lacrimal gland, dry eye disease, tears, neurostimulationYu MDPark JKKossler ALDove Medical Pressarticleoculoplastics ocular surface cornea lacrimal gland dry eye disease tears neurostimulationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4219-4226 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oculoplastics ocular surface cornea lacrimal gland dry eye disease tears neurostimulation Ophthalmology RE1-994
spellingShingle	oculoplastics ocular surface cornea lacrimal gland dry eye disease tears neurostimulation Ophthalmology RE1-994 Yu MD Park JK Kossler AL Stimulating Tear Production: Spotlight on Neurostimulation
description	Michael D Yu,1 Ji Kwan Park,2 Andrea L Kossler1 1Oculoplastic Surgery and Orbital Oncology Service, Byers Eye Institute, Stanford University, Palo Alto, CA, USA; 2Oculofacial Plastic and Orbital Surgery, Indianapolis, IN, USACorrespondence: Andrea L KosslerOculoplastic Surgery and Orbital Oncology Service, Byers Eye Institute, Stanford University, 2452 Watson Ct, Palo Alto, CA 94303, USATel +1 650-724-0105Email akossler@stanford.eduAbstract: Dry eye disease (DED) affects up to one-third of the global population. Traditional therapies, including topical lubricants, have been employed with variable success in the treatment of DED. Recently, neurostimulation of the lacrimal functional unit (LFU) has emerged as a promising alternative therapy for DED. In this review, we describe the neuroanatomical and pathophysiological considerations of DED and the LFU that make neurostimulation a viable therapeutic alternative. We further detail the various neurostimulatory approaches taken thus far—from implanted stimulators to external devices to chemical neurostimulation. Existing studies reveal the strengths of the neurostimulatory approach in increasing tear volume and improving dry eye symptoms, but further studies are needed to elucidate its true potential in treatment of DED.Keywords: oculoplastics, ocular surface, cornea, lacrimal gland, dry eye disease, tears, neurostimulation
format	article
author	Yu MD Park JK Kossler AL
author_facet	Yu MD Park JK Kossler AL
author_sort	Yu MD
title	Stimulating Tear Production: Spotlight on Neurostimulation
title_short	Stimulating Tear Production: Spotlight on Neurostimulation
title_full	Stimulating Tear Production: Spotlight on Neurostimulation
title_fullStr	Stimulating Tear Production: Spotlight on Neurostimulation
title_full_unstemmed	Stimulating Tear Production: Spotlight on Neurostimulation
title_sort	stimulating tear production: spotlight on neurostimulation
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/da00489aec2c450d8e59d5409aabe878
work_keys_str_mv	AT yumd stimulatingtearproductionspotlightonneurostimulation AT parkjk stimulatingtearproductionspotlightonneurostimulation AT kossleral stimulatingtearproductionspotlightonneurostimulation
_version_	1718379076976115712

Stimulating Tear Production: Spotlight on Neurostimulation

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