Systematic analysis of protein turnover in primary cells

Systematic analysis of protein turnover in primary cells

The proteome-wide characterization of proteostasis depends on robust approaches to determine protein half-lives. Here, the authors improve the accuracy and precision of mass spectrometry-based quantification, enabling reliable protein half-life determination in several non-dividing cell types.

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Bibliographic Details
Main Authors: Toby Mathieson, Holger Franken, Jan Kosinski, Nils Kurzawa, Nico Zinn, Gavain Sweetman, Daniel Poeckel, Vikram S. Ratnu, Maike Schramm, Isabelle Becher, Michael Steidel, Kyung-Min Noh, Giovanna Bergamini, Martin Beck, Marcus Bantscheff, Mikhail M. Savitski
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/da0726d0c6b44f4fa437f686bacfcd20
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Internet

https://doaj.org/article/da0726d0c6b44f4fa437f686bacfcd20

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