Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)

Background: High sodium intake is an important risk factor for hypertension and cardiovascular disease. However, the association between gut microbiota composition and metabolomic profiles with dietary sodium intake and blood pressure (BP) is not well-understood. The metabolome, microbiome, and diet...

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Autores principales:	Zengliang Ruan, Jianxin Li, Fangchao Liu, Jie Cao, Shufeng Chen, Jichun Chen, Keyong Huang, Yaqin Wang, Hongfan Li, Yan Wang, Zhongyu Xue, Laiyuan Wang, Jianfeng Huang, Dongfeng Gu, Xiangfeng Lu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Dietary sodium Metabolome Microbiota Blood pressure Hypertension Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/da0831f253df47599542814f496748d6
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spelling	oai:doaj.org-article:da0831f253df47599542814f496748d62021-12-02T19:33:21ZStudy design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)2095-882X10.1016/j.cdtm.2021.06.002https://doaj.org/article/da0831f253df47599542814f496748d62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X21000451https://doaj.org/toc/2095-882XBackground: High sodium intake is an important risk factor for hypertension and cardiovascular disease. However, the association between gut microbiota composition and metabolomic profiles with dietary sodium intake and blood pressure (BP) is not well-understood. The metabolome, microbiome, and dietary salt intervention (MetaSalt) study aimed to investigate microbial and metabolomic profiles related to dietary sodium intake and BP regulation. Methods: This family-based intervention study was conducted in four communities across three provinces in rural northern China in 2019. Probands with untreated prehypertension or stage-1 hypertension were identified through community-based BP screening, and family members including siblings, offspring, spouses, and parents were subsequently included. All participants participated in a 3-day baseline examination with usual diet consumption, followed by a 10-day low-salt diet (3 g/d of salt or 51.3 mmol/d of sodium) and a 10-day high-salt diet (18 g/d of salt or 307.8 mmol/d of sodium). Differences in mean BP levels were compared according to the intervention phases using a paired Student's t-test. Results: A total of 528 participants were included in this study, with a mean age of 48.1 years, 36.7% of whom were male, 76.8% had a middle school (69.7%) or higher (7.1%) diploma, 23.4% had a history of smoking, and 24.4% were current drinkers. The mean arterial pressure at baseline was 97.2 ± 10.5 mm Hg for all participants, and significantly decreased during the low-salt intervention (93.8 ± 9.3, P < 0.0001) and subsequently increased during the high-salt intervention (96.4 ± 10.0, P < 0.0001). Conclusions: Our dietary salt intervention study has successfully recruited participants and will facilitate to evaluate the effects of gut microbiota and metabolites on BP regulation in response to sodium burden, which will provide important evidence for investigating the underlying mechanisms in the development of hypertension and subsequent cardiovascular diseases. Trial registration: The study was registered in the Chinese Clinical Trial Registry database (ChiCTR1900025171).Zengliang RuanJianxin LiFangchao LiuJie CaoShufeng ChenJichun ChenKeyong HuangYaqin WangHongfan LiYan WangZhongyu XueLaiyuan WangJianfeng HuangDongfeng GuXiangfeng LuKeAi Communications Co., Ltd.articleDietary sodiumMetabolomeMicrobiotaBlood pressureHypertensionMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 7, Iss 4, Pp 227-234 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dietary sodium Metabolome Microbiota Blood pressure Hypertension Medicine (General) R5-920
spellingShingle	Dietary sodium Metabolome Microbiota Blood pressure Hypertension Medicine (General) R5-920 Zengliang Ruan Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Zhongyu Xue Laiyuan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)
description	Background: High sodium intake is an important risk factor for hypertension and cardiovascular disease. However, the association between gut microbiota composition and metabolomic profiles with dietary sodium intake and blood pressure (BP) is not well-understood. The metabolome, microbiome, and dietary salt intervention (MetaSalt) study aimed to investigate microbial and metabolomic profiles related to dietary sodium intake and BP regulation. Methods: This family-based intervention study was conducted in four communities across three provinces in rural northern China in 2019. Probands with untreated prehypertension or stage-1 hypertension were identified through community-based BP screening, and family members including siblings, offspring, spouses, and parents were subsequently included. All participants participated in a 3-day baseline examination with usual diet consumption, followed by a 10-day low-salt diet (3 g/d of salt or 51.3 mmol/d of sodium) and a 10-day high-salt diet (18 g/d of salt or 307.8 mmol/d of sodium). Differences in mean BP levels were compared according to the intervention phases using a paired Student's t-test. Results: A total of 528 participants were included in this study, with a mean age of 48.1 years, 36.7% of whom were male, 76.8% had a middle school (69.7%) or higher (7.1%) diploma, 23.4% had a history of smoking, and 24.4% were current drinkers. The mean arterial pressure at baseline was 97.2 ± 10.5 mm Hg for all participants, and significantly decreased during the low-salt intervention (93.8 ± 9.3, P < 0.0001) and subsequently increased during the high-salt intervention (96.4 ± 10.0, P < 0.0001). Conclusions: Our dietary salt intervention study has successfully recruited participants and will facilitate to evaluate the effects of gut microbiota and metabolites on BP regulation in response to sodium burden, which will provide important evidence for investigating the underlying mechanisms in the development of hypertension and subsequent cardiovascular diseases. Trial registration: The study was registered in the Chinese Clinical Trial Registry database (ChiCTR1900025171).
format	article
author	Zengliang Ruan Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Zhongyu Xue Laiyuan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu
author_facet	Zengliang Ruan Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Zhongyu Xue Laiyuan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu
author_sort	Zengliang Ruan
title	Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)
title_short	Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)
title_full	Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)
title_fullStr	Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)
title_full_unstemmed	Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)
title_sort	study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (metasalt)
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/da0831f253df47599542814f496748d6
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Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt)

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