Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review

Although breast cancer has been previously considered “cold” tumors, numerous studies are currently conducted to explore the great potentials of immunotherapies in improving breast cancer patient outcomes. In addition to the focus on stimulating adaptive immunity for antitumor responses, growing evi...

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Autores principales:	Yanqi Ye, Chun Xu, Fengqian Chen, Qi Liu, Ning Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	innate immunity breast cancer cancer immunotherapy clinical studies vaccine adjuvants Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/da0aefefad5f44e792d183cd16bb583a
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spelling	oai:doaj.org-article:da0aefefad5f44e792d183cd16bb583a2021-12-01T02:30:09ZTargeting Innate Immunity in Breast Cancer Therapy: A Narrative Review1664-322410.3389/fimmu.2021.771201https://doaj.org/article/da0aefefad5f44e792d183cd16bb583a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.771201/fullhttps://doaj.org/toc/1664-3224Although breast cancer has been previously considered “cold” tumors, numerous studies are currently conducted to explore the great potentials of immunotherapies in improving breast cancer patient outcomes. In addition to the focus on stimulating adaptive immunity for antitumor responses, growing evidence showed the importance of triggering host innate immunity to eradicate established tumors and/or control tumor metastasis of breast cancer. In this review, we first briefly introduce the breast tumor immune microenvironment. We also discuss innate immune targets and pathways and mechanisms of their synergy with the adaptive antitumor response and other treatment strategies. Lastly, we review clinical trials targeting innate immune pathways for breast cancer therapies.Yanqi YeChun XuFengqian ChenQi LiuNing ChengFrontiers Media S.A.articleinnate immunitybreast cancercancer immunotherapyclinical studiesvaccine adjuvantsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	innate immunity breast cancer cancer immunotherapy clinical studies vaccine adjuvants Immunologic diseases. Allergy RC581-607
spellingShingle	innate immunity breast cancer cancer immunotherapy clinical studies vaccine adjuvants Immunologic diseases. Allergy RC581-607 Yanqi Ye Chun Xu Fengqian Chen Qi Liu Ning Cheng Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review
description	Although breast cancer has been previously considered “cold” tumors, numerous studies are currently conducted to explore the great potentials of immunotherapies in improving breast cancer patient outcomes. In addition to the focus on stimulating adaptive immunity for antitumor responses, growing evidence showed the importance of triggering host innate immunity to eradicate established tumors and/or control tumor metastasis of breast cancer. In this review, we first briefly introduce the breast tumor immune microenvironment. We also discuss innate immune targets and pathways and mechanisms of their synergy with the adaptive antitumor response and other treatment strategies. Lastly, we review clinical trials targeting innate immune pathways for breast cancer therapies.
format	article
author	Yanqi Ye Chun Xu Fengqian Chen Qi Liu Ning Cheng
author_facet	Yanqi Ye Chun Xu Fengqian Chen Qi Liu Ning Cheng
author_sort	Yanqi Ye
title	Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review
title_short	Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review
title_full	Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review
title_fullStr	Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review
title_full_unstemmed	Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review
title_sort	targeting innate immunity in breast cancer therapy: a narrative review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/da0aefefad5f44e792d183cd16bb583a
work_keys_str_mv	AT yanqiye targetinginnateimmunityinbreastcancertherapyanarrativereview AT chunxu targetinginnateimmunityinbreastcancertherapyanarrativereview AT fengqianchen targetinginnateimmunityinbreastcancertherapyanarrativereview AT qiliu targetinginnateimmunityinbreastcancertherapyanarrativereview AT ningcheng targetinginnateimmunityinbreastcancertherapyanarrativereview
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Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review

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