Algorithms for optoacoustically controlled selective retina therapy (SRT)

Objectives: Selective Retina Therapy (SRT) uses microbubble formation (MBF) to target retinal pigment epithelium (RPE) cells selectively while sparing the neural retina and the choroid. Intra- and inter-individual variations of RPE pigmentation makes frequent radiant exposure adaption necessary. Sin...

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Autores principales:	Eric Seifert, Jan Tode, Amelie Pielen, Dirk Theisen-Kunde, Carsten Framme, Johann Roider, Yoko Miura, Reginald Birngruber, Ralf Brinkmann
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	SRT Lasers in medicine Ophthalmology RPE Selectivity Algorithm Physics QC1-999 Acoustics. Sound QC221-246 Optics. Light QC350-467
Acceso en línea:	https://doaj.org/article/da0b9e97ffcf4d4d88f2fa6ec58a336f
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spelling	oai:doaj.org-article:da0b9e97ffcf4d4d88f2fa6ec58a336f2021-12-04T04:34:12ZAlgorithms for optoacoustically controlled selective retina therapy (SRT)2213-597910.1016/j.pacs.2021.100316https://doaj.org/article/da0b9e97ffcf4d4d88f2fa6ec58a336f2022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213597921000756https://doaj.org/toc/2213-5979Objectives: Selective Retina Therapy (SRT) uses microbubble formation (MBF) to target retinal pigment epithelium (RPE) cells selectively while sparing the neural retina and the choroid. Intra- and inter-individual variations of RPE pigmentation makes frequent radiant exposure adaption necessary. Since selective RPE cell disintegration is ophthalmoscopically non-visible, MBF detection techniques are useful to control adequate radiant exposures. It was the purpose of this study to evaluate optoacoustically based MBF detection algorithms. Methods: Fifteen patients suffering from central serous chorioretinopathy and diabetic macula edema were treated with a SRT laser using a wavelength of 527 nm, a pulse duration of 1.7 µs and a pulse energy ramp (15 pulses, 100 Hz repetition rate). An ultrasonic transducer for MBF detection was embedded in a contact lens. RPE damage was verified with fluorescence angiography. Results: An algorithm to detect MBF as an indicator for RPE cell damage was evaluated. Overall, 4646 irradiations were used for algorithm optimization and testing. The tested algorithms were superior to a baseline model. A sensitivity/specificity pair of 0.96/1 was achieved. The few false algorithmic decisions were caused by unevaluable signals. Conclusions: The algorithm can be used for guidance or automatization of microbubble related treatments like SRT or selective laser trabeculoplasty (SLT).Eric SeifertJan TodeAmelie PielenDirk Theisen-KundeCarsten FrammeJohann RoiderYoko MiuraReginald BirngruberRalf BrinkmannElsevierarticleSRTLasers in medicineOphthalmologyRPESelectivityAlgorithmPhysicsQC1-999Acoustics. SoundQC221-246Optics. LightQC350-467ENPhotoacoustics, Vol 25, Iss , Pp 100316- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	SRT Lasers in medicine Ophthalmology RPE Selectivity Algorithm Physics QC1-999 Acoustics. Sound QC221-246 Optics. Light QC350-467
spellingShingle	SRT Lasers in medicine Ophthalmology RPE Selectivity Algorithm Physics QC1-999 Acoustics. Sound QC221-246 Optics. Light QC350-467 Eric Seifert Jan Tode Amelie Pielen Dirk Theisen-Kunde Carsten Framme Johann Roider Yoko Miura Reginald Birngruber Ralf Brinkmann Algorithms for optoacoustically controlled selective retina therapy (SRT)
description	Objectives: Selective Retina Therapy (SRT) uses microbubble formation (MBF) to target retinal pigment epithelium (RPE) cells selectively while sparing the neural retina and the choroid. Intra- and inter-individual variations of RPE pigmentation makes frequent radiant exposure adaption necessary. Since selective RPE cell disintegration is ophthalmoscopically non-visible, MBF detection techniques are useful to control adequate radiant exposures. It was the purpose of this study to evaluate optoacoustically based MBF detection algorithms. Methods: Fifteen patients suffering from central serous chorioretinopathy and diabetic macula edema were treated with a SRT laser using a wavelength of 527 nm, a pulse duration of 1.7 µs and a pulse energy ramp (15 pulses, 100 Hz repetition rate). An ultrasonic transducer for MBF detection was embedded in a contact lens. RPE damage was verified with fluorescence angiography. Results: An algorithm to detect MBF as an indicator for RPE cell damage was evaluated. Overall, 4646 irradiations were used for algorithm optimization and testing. The tested algorithms were superior to a baseline model. A sensitivity/specificity pair of 0.96/1 was achieved. The few false algorithmic decisions were caused by unevaluable signals. Conclusions: The algorithm can be used for guidance or automatization of microbubble related treatments like SRT or selective laser trabeculoplasty (SLT).
format	article
author	Eric Seifert Jan Tode Amelie Pielen Dirk Theisen-Kunde Carsten Framme Johann Roider Yoko Miura Reginald Birngruber Ralf Brinkmann
author_facet	Eric Seifert Jan Tode Amelie Pielen Dirk Theisen-Kunde Carsten Framme Johann Roider Yoko Miura Reginald Birngruber Ralf Brinkmann
author_sort	Eric Seifert
title	Algorithms for optoacoustically controlled selective retina therapy (SRT)
title_short	Algorithms for optoacoustically controlled selective retina therapy (SRT)
title_full	Algorithms for optoacoustically controlled selective retina therapy (SRT)
title_fullStr	Algorithms for optoacoustically controlled selective retina therapy (SRT)
title_full_unstemmed	Algorithms for optoacoustically controlled selective retina therapy (SRT)
title_sort	algorithms for optoacoustically controlled selective retina therapy (srt)
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/da0b9e97ffcf4d4d88f2fa6ec58a336f
work_keys_str_mv	AT ericseifert algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt AT jantode algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt AT ameliepielen algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt AT dirktheisenkunde algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt AT carstenframme algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt AT johannroider algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt AT yokomiura algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt AT reginaldbirngruber algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt AT ralfbrinkmann algorithmsforoptoacousticallycontrolledselectiveretinatherapysrt
_version_	1718372998101073920

Algorithms for optoacoustically controlled selective retina therapy (SRT)

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