Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma

Abstract Cancer frequently arises in epithelial tissues subjected to repeated cycles of injury and repair. Improving our understanding of tissue regeneration is, therefore, likely to reveal novel processes with inherent potential for aberration that can lead to carcinoma. These highly conserved rege...

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Autores principales:	R. V. Guest, L. Boulter, B. J. Dwyer, S. J. Forbes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/da0e81fe28b04af4a753bfc50253db6a
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spelling	oai:doaj.org-article:da0e81fe28b04af4a753bfc50253db6a2021-12-02T14:22:13ZUnderstanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma10.1038/s41536-017-0018-z2057-3995https://doaj.org/article/da0e81fe28b04af4a753bfc50253db6a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0018-zhttps://doaj.org/toc/2057-3995Abstract Cancer frequently arises in epithelial tissues subjected to repeated cycles of injury and repair. Improving our understanding of tissue regeneration is, therefore, likely to reveal novel processes with inherent potential for aberration that can lead to carcinoma. These highly conserved regenerative mechanisms are increasingly understood and in the liver are associated with special characteristics that underlie the organ’s legendary capacity for restoration of size and function following even severe or chronic injury. The nature of the injury can determine the cellular source of epithelial regeneration and the signalling mechanisms brought to play. These observations are shaping how we understand and experimentally investigate primary liver cancer, in particular cholangiocarcinoma; a highly invasive malignancy of the bile ducts, resistant to chemotherapy and whose pathogenesis has hitherto been poorly understood. Interestingly, signals that drive liver development become activated in the formation of cholangiocarcinoma, such as Notch and Wnt and may be potential future therapeutic targets. In this review, we summarise the work which has led to the current understanding of the cellular source of cholangiocarcinoma, how the tumour recruits, sustains and is educated by its supporting stromal environment, and the tumour-derived signals that drive the progression and invasion of the cancer. With few current treatments of any true efficacy, advances that will improve our understanding of the mechanisms driving this aggressive malignancy are welcome and may help drive therapeutic developments.R. V. GuestL. BoulterB. J. DwyerS. J. ForbesNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R R. V. Guest L. Boulter B. J. Dwyer S. J. Forbes Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
description	Abstract Cancer frequently arises in epithelial tissues subjected to repeated cycles of injury and repair. Improving our understanding of tissue regeneration is, therefore, likely to reveal novel processes with inherent potential for aberration that can lead to carcinoma. These highly conserved regenerative mechanisms are increasingly understood and in the liver are associated with special characteristics that underlie the organ’s legendary capacity for restoration of size and function following even severe or chronic injury. The nature of the injury can determine the cellular source of epithelial regeneration and the signalling mechanisms brought to play. These observations are shaping how we understand and experimentally investigate primary liver cancer, in particular cholangiocarcinoma; a highly invasive malignancy of the bile ducts, resistant to chemotherapy and whose pathogenesis has hitherto been poorly understood. Interestingly, signals that drive liver development become activated in the formation of cholangiocarcinoma, such as Notch and Wnt and may be potential future therapeutic targets. In this review, we summarise the work which has led to the current understanding of the cellular source of cholangiocarcinoma, how the tumour recruits, sustains and is educated by its supporting stromal environment, and the tumour-derived signals that drive the progression and invasion of the cancer. With few current treatments of any true efficacy, advances that will improve our understanding of the mechanisms driving this aggressive malignancy are welcome and may help drive therapeutic developments.
format	article
author	R. V. Guest L. Boulter B. J. Dwyer S. J. Forbes
author_facet	R. V. Guest L. Boulter B. J. Dwyer S. J. Forbes
author_sort	R. V. Guest
title	Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
title_short	Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
title_full	Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
title_fullStr	Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
title_full_unstemmed	Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
title_sort	understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/da0e81fe28b04af4a753bfc50253db6a
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Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma

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