A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats

Animals constantly balance seeking food with avoiding predators. Here, the authors report that CRF positive neurons in the paraventricular thalamus projecting to the nucleus accumbens in rats are an indispensable component of a feedback circuit that can interrupt appetitive behaviour in favor of a d...

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Autores principales: D. S. Engelke, X. O. Zhang, J. J. O’Malley, J. A. Fernandez-Leon, S. Li, G. J. Kirouac, M. Beierlein, F. H. Do-Monte
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/da0fbb3253a641e9a1dab25e6c597513
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Sumario:Animals constantly balance seeking food with avoiding predators. Here, the authors report that CRF positive neurons in the paraventricular thalamus projecting to the nucleus accumbens in rats are an indispensable component of a feedback circuit that can interrupt appetitive behaviour in favor of a defensive response in the presence of a competing threat stimulus.