Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease

In chronic disorders such as Parkinson’s disease (PD), fear of falling (FOF) is associated with falls and reduced quality of life. With inertial measurement units (IMUs) and dedicated algorithms, different aspects of mobility can be obtained during supervised tests in the lab and also during daily a...

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Autores principales:	Arash Atrsaei, Clint Hansen, Morad Elshehabi, Susanne Solbrig, Daniela Berg, Inga Liepelt-Scarfone, Walter Maetzler, Kamiar Aminian
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	inertial sensor wearables sit-to-stand gait turning timed-up and go Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/da107170a89e4c7e91406ebaab09b560
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spelling	oai:doaj.org-article:da107170a89e4c7e91406ebaab09b5602021-12-01T18:26:37ZEffect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease1663-436510.3389/fnagi.2021.722830https://doaj.org/article/da107170a89e4c7e91406ebaab09b5602021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.722830/fullhttps://doaj.org/toc/1663-4365In chronic disorders such as Parkinson’s disease (PD), fear of falling (FOF) is associated with falls and reduced quality of life. With inertial measurement units (IMUs) and dedicated algorithms, different aspects of mobility can be obtained during supervised tests in the lab and also during daily activities. To our best knowledge, the effect of FOF on mobility has not been investigated in both of these settings simultaneously. Our goal was to evaluate the effect of FOF on the mobility of 26 patients with PD during clinical assessments and 14 days of daily activity monitoring. Parameters related to gait, sit-to-stand transitions, and turns were extracted from IMU signals on the lower back. Fear of falling was assessed using the Falls Efficacy Scale-International (FES-I) and the patients were grouped as with (PD-FOF+) and without FOF (PD-FOF−). Mobility parameters between groups were compared using logistic regression as well as the effect size values obtained using the Wilcoxon rank-sum test. The peak angular velocity of the turn-to-sit transition of the timed-up-and-go (TUG) test had the highest discriminative power between PD-FOF+ and PD-FOF− (r-value of effect size = 0.61). Moreover, PD-FOF+ had a tendency toward lower gait speed at home and a lower amount of walking bouts, especially for shorter walking bouts. The combination of lab and daily activity parameters reached a higher discriminative power [area under the curve (AUC) = 0.75] than each setting alone (AUC = 0.68 in the lab, AUC = 0.54 at home). Comparing the gait speed between the two assessments, the PD-FOF+ showed higher gait speeds in the capacity area compared with their TUG test in the lab. The mobility parameters extracted from both lab and home-based assessments contribute to the detection of FOF in PD. This study adds further evidence to the usefulness of mobility assessments that include different environments and assessment strategies. Although this study was limited in the sample size, it still provides a helpful method to consider the daily activity measurement of the patients with PD into clinical evaluation. The obtained results can help the clinicians with a more accurate prevention and treatment strategy.Arash AtrsaeiClint HansenMorad ElshehabiSusanne SolbrigSusanne SolbrigDaniela BergDaniela BergDaniela BergInga Liepelt-ScarfoneInga Liepelt-ScarfoneInga Liepelt-ScarfoneWalter MaetzlerKamiar AminianFrontiers Media S.A.articleinertial sensorwearablessit-to-standgaitturningtimed-up and goNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inertial sensor wearables sit-to-stand gait turning timed-up and go Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	inertial sensor wearables sit-to-stand gait turning timed-up and go Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Arash Atrsaei Clint Hansen Morad Elshehabi Susanne Solbrig Susanne Solbrig Daniela Berg Daniela Berg Daniela Berg Inga Liepelt-Scarfone Inga Liepelt-Scarfone Inga Liepelt-Scarfone Walter Maetzler Kamiar Aminian Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease
description	In chronic disorders such as Parkinson’s disease (PD), fear of falling (FOF) is associated with falls and reduced quality of life. With inertial measurement units (IMUs) and dedicated algorithms, different aspects of mobility can be obtained during supervised tests in the lab and also during daily activities. To our best knowledge, the effect of FOF on mobility has not been investigated in both of these settings simultaneously. Our goal was to evaluate the effect of FOF on the mobility of 26 patients with PD during clinical assessments and 14 days of daily activity monitoring. Parameters related to gait, sit-to-stand transitions, and turns were extracted from IMU signals on the lower back. Fear of falling was assessed using the Falls Efficacy Scale-International (FES-I) and the patients were grouped as with (PD-FOF+) and without FOF (PD-FOF−). Mobility parameters between groups were compared using logistic regression as well as the effect size values obtained using the Wilcoxon rank-sum test. The peak angular velocity of the turn-to-sit transition of the timed-up-and-go (TUG) test had the highest discriminative power between PD-FOF+ and PD-FOF− (r-value of effect size = 0.61). Moreover, PD-FOF+ had a tendency toward lower gait speed at home and a lower amount of walking bouts, especially for shorter walking bouts. The combination of lab and daily activity parameters reached a higher discriminative power [area under the curve (AUC) = 0.75] than each setting alone (AUC = 0.68 in the lab, AUC = 0.54 at home). Comparing the gait speed between the two assessments, the PD-FOF+ showed higher gait speeds in the capacity area compared with their TUG test in the lab. The mobility parameters extracted from both lab and home-based assessments contribute to the detection of FOF in PD. This study adds further evidence to the usefulness of mobility assessments that include different environments and assessment strategies. Although this study was limited in the sample size, it still provides a helpful method to consider the daily activity measurement of the patients with PD into clinical evaluation. The obtained results can help the clinicians with a more accurate prevention and treatment strategy.
format	article
author	Arash Atrsaei Clint Hansen Morad Elshehabi Susanne Solbrig Susanne Solbrig Daniela Berg Daniela Berg Daniela Berg Inga Liepelt-Scarfone Inga Liepelt-Scarfone Inga Liepelt-Scarfone Walter Maetzler Kamiar Aminian
author_facet	Arash Atrsaei Clint Hansen Morad Elshehabi Susanne Solbrig Susanne Solbrig Daniela Berg Daniela Berg Daniela Berg Inga Liepelt-Scarfone Inga Liepelt-Scarfone Inga Liepelt-Scarfone Walter Maetzler Kamiar Aminian
author_sort	Arash Atrsaei
title	Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease
title_short	Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease
title_full	Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease
title_fullStr	Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease
title_full_unstemmed	Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease
title_sort	effect of fear of falling on mobility measured during lab and daily activity assessments in parkinson’s disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/da107170a89e4c7e91406ebaab09b560
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Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson’s Disease

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