Single-molecule analysis of steroid receptor and cofactor action in living cells

Transcription factors (TFs) are thought to regulate gene expression by stably binding to target DNA elements. Here, the authors use single-molecule tracking to analyse the dynamic behaviour of steroid receptors TFs and show that most specific interactions with chromatin are transient and dynamic.

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Autores principales:	Ville Paakinaho, Diego M. Presman, David A. Ball, Thomas A. Johnson, R. Louis Schiltz, Peter Levitt, Davide Mazza, Tatsuya Morisaki, Tatiana S. Karpova, Gordon L. Hager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da11fc1b218545cd940439b7efb072c6
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spelling	oai:doaj.org-article:da11fc1b218545cd940439b7efb072c62021-12-02T17:01:24ZSingle-molecule analysis of steroid receptor and cofactor action in living cells10.1038/ncomms158962041-1723https://doaj.org/article/da11fc1b218545cd940439b7efb072c62017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15896https://doaj.org/toc/2041-1723Transcription factors (TFs) are thought to regulate gene expression by stably binding to target DNA elements. Here, the authors use single-molecule tracking to analyse the dynamic behaviour of steroid receptors TFs and show that most specific interactions with chromatin are transient and dynamic.Ville PaakinahoDiego M. PresmanDavid A. BallThomas A. JohnsonR. Louis SchiltzPeter LevittDavide MazzaTatsuya MorisakiTatiana S. KarpovaGordon L. HagerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ville Paakinaho Diego M. Presman David A. Ball Thomas A. Johnson R. Louis Schiltz Peter Levitt Davide Mazza Tatsuya Morisaki Tatiana S. Karpova Gordon L. Hager Single-molecule analysis of steroid receptor and cofactor action in living cells
description	Transcription factors (TFs) are thought to regulate gene expression by stably binding to target DNA elements. Here, the authors use single-molecule tracking to analyse the dynamic behaviour of steroid receptors TFs and show that most specific interactions with chromatin are transient and dynamic.
format	article
author	Ville Paakinaho Diego M. Presman David A. Ball Thomas A. Johnson R. Louis Schiltz Peter Levitt Davide Mazza Tatsuya Morisaki Tatiana S. Karpova Gordon L. Hager
author_facet	Ville Paakinaho Diego M. Presman David A. Ball Thomas A. Johnson R. Louis Schiltz Peter Levitt Davide Mazza Tatsuya Morisaki Tatiana S. Karpova Gordon L. Hager
author_sort	Ville Paakinaho
title	Single-molecule analysis of steroid receptor and cofactor action in living cells
title_short	Single-molecule analysis of steroid receptor and cofactor action in living cells
title_full	Single-molecule analysis of steroid receptor and cofactor action in living cells
title_fullStr	Single-molecule analysis of steroid receptor and cofactor action in living cells
title_full_unstemmed	Single-molecule analysis of steroid receptor and cofactor action in living cells
title_sort	single-molecule analysis of steroid receptor and cofactor action in living cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/da11fc1b218545cd940439b7efb072c6
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Single-molecule analysis of steroid receptor and cofactor action in living cells

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