Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.

A fundamental question in biology is how multicellular organisms distinguish self and non-self. The ability to make this distinction allows animals and plants to detect and respond to pathogens without triggering immune reactions directed against their own cells. In plants, inappropriate self-recogn...

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Autores principales:	Marco Todesco, Sang-Tae Kim, Eunyoung Chae, Kirsten Bomblies, Maricris Zaidem, Lisa M Smith, Detlef Weigel, Roosa A E Laitinen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/da166557f41241609271999feebdd5e0
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spelling	oai:doaj.org-article:da166557f41241609271999feebdd5e02021-11-25T05:51:48ZActivation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.1553-73901553-740410.1371/journal.pgen.1004459https://doaj.org/article/da166557f41241609271999feebdd5e02014-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25010663/pdf/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404A fundamental question in biology is how multicellular organisms distinguish self and non-self. The ability to make this distinction allows animals and plants to detect and respond to pathogens without triggering immune reactions directed against their own cells. In plants, inappropriate self-recognition results in the autonomous activation of the immune system, causing affected individuals to grow less well. These plants also suffer from spontaneous cell death, but are at the same time more resistant to pathogens. Known causes for such autonomous activation of the immune system are hyperactive alleles of immune regulators, or epistatic interactions between immune regulators and unlinked genes. We have discovered a third class, in which the Arabidopsis thaliana immune system is activated by interactions between natural alleles at a single locus, ACCELERATED CELL DEATH 6 (ACD6). There are two main types of these interacting alleles, one of which has evolved recently by partial resurrection of a pseudogene, and each type includes multiple functional variants. Most previously studies hybrid necrosis cases involve rare alleles found in geographically unrelated populations. These two types of ACD6 alleles instead occur at low frequency throughout the range of the species, and have risen to high frequency in the Northeast of Spain, suggesting a role in local adaptation. In addition, such hybrids occur in these populations in the wild. The extensive functional variation among ACD6 alleles points to a central role of this locus in fine-tuning pathogen defenses in natural populations.Marco TodescoSang-Tae KimEunyoung ChaeKirsten BombliesMaricris ZaidemLisa M SmithDetlef WeigelRoosa A E LaitinenPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 10, Iss 7, p e1004459 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Marco Todesco Sang-Tae Kim Eunyoung Chae Kirsten Bomblies Maricris Zaidem Lisa M Smith Detlef Weigel Roosa A E Laitinen Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.
description	A fundamental question in biology is how multicellular organisms distinguish self and non-self. The ability to make this distinction allows animals and plants to detect and respond to pathogens without triggering immune reactions directed against their own cells. In plants, inappropriate self-recognition results in the autonomous activation of the immune system, causing affected individuals to grow less well. These plants also suffer from spontaneous cell death, but are at the same time more resistant to pathogens. Known causes for such autonomous activation of the immune system are hyperactive alleles of immune regulators, or epistatic interactions between immune regulators and unlinked genes. We have discovered a third class, in which the Arabidopsis thaliana immune system is activated by interactions between natural alleles at a single locus, ACCELERATED CELL DEATH 6 (ACD6). There are two main types of these interacting alleles, one of which has evolved recently by partial resurrection of a pseudogene, and each type includes multiple functional variants. Most previously studies hybrid necrosis cases involve rare alleles found in geographically unrelated populations. These two types of ACD6 alleles instead occur at low frequency throughout the range of the species, and have risen to high frequency in the Northeast of Spain, suggesting a role in local adaptation. In addition, such hybrids occur in these populations in the wild. The extensive functional variation among ACD6 alleles points to a central role of this locus in fine-tuning pathogen defenses in natural populations.
format	article
author	Marco Todesco Sang-Tae Kim Eunyoung Chae Kirsten Bomblies Maricris Zaidem Lisa M Smith Detlef Weigel Roosa A E Laitinen
author_facet	Marco Todesco Sang-Tae Kim Eunyoung Chae Kirsten Bomblies Maricris Zaidem Lisa M Smith Detlef Weigel Roosa A E Laitinen
author_sort	Marco Todesco
title	Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.
title_short	Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.
title_full	Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.
title_fullStr	Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.
title_full_unstemmed	Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.
title_sort	activation of the arabidopsis thaliana immune system by combinations of common acd6 alleles.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/da166557f41241609271999feebdd5e0
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Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.

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