Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ.

Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ.

<h4>Background</h4>Two different Th2 subsets have been defined recently on the basis of IL-5 expression - an IL-5(+)Th2 subset and an IL-5(-)Th2 subset in the setting of allergy. However, the role of these newly described CD4(+) T cells subpopulations has not been explored in other conte...

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Autores principales: Rajamanickam Anuradha, Parakkal Jovvian George, Luke E Hanna, Vedachalam Chandrasekaran, P Paul Kumaran, Thomas B Nutman, Subash Babu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Acceso en línea:https://doaj.org/article/da18b081ab5b4f7f918f568fb5dbcaa0
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