Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane

Stefano Zenoni1, Mario R Romano2, Sonia Palmieri1, Natalia Comi1, Edoardo Fiorentini1, Piero Fontana11Ospedali Riuniti di Bergamo, Bergamo, Italy; 2Istituto Clinico Humanitas IRCSS, Rozzano, Milan, ItalyObjective: The aim of the study was to evaluate the ocular tolerance and efficacy of double filli...

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Autores principales:	Zenoni S, Romano MR, Palmieri S, Comi N, Fiorentini E, Fontana P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/da19d70c32ef4f768230d33295dea7c2
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spelling	oai:doaj.org-article:da19d70c32ef4f768230d33295dea7c22021-12-02T05:54:39ZOcular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane1177-54671177-5483https://doaj.org/article/da19d70c32ef4f768230d33295dea7c22011-04-01T00:00:00Zhttp://www.dovepress.com/ocular-tolerance-and-efficacy-of-short-term-tamponade-with-double-fill-a7021https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Stefano Zenoni1, Mario R Romano2, Sonia Palmieri1, Natalia Comi1, Edoardo Fiorentini1, Piero Fontana11Ospedali Riuniti di Bergamo, Bergamo, Italy; 2Istituto Clinico Humanitas IRCSS, Rozzano, Milan, ItalyObjective: The aim of the study was to evaluate the ocular tolerance and efficacy of double filling with perfluoro-n-octane (n-C8F18) (PFO) and polydimethyloxane (PDMS) as a temporary vitreous substitute in patients with retinal detachment complicated by proliferative vitreoretinopathy (PVR).Material and methods: Tamponade was performed in 30 eyes of 30 patients by double filling with 30% PFO and 70% PDMS for an average of 23 (standard deviation 2.2) days. The follow-up visits were scheduled 1 week, 1 month, and 3 months after surgery. The main outcome measures were visual acuity, intraocular pressure (IOP), PVR reproliferation, and electrophysiological parameters.Results: The primary success rate was 80% (24/30). Fourteen patients (46.7%) had a postoperative improvement in visual acuity, 12 patients (40.0%) maintained their preoperative visual acuity, and four patients (13.3%) experienced a reduction in visual acuity. The mean postoperative IOP was 19.7 mm Hg (11&ndash;32 mm Hg); nine cases (30.0%) developed an IOP increase that was treated with topical drops and/or systemic carbonic anhydrase inhibitors. The electroretinogram (ERG) and the bright flash electroretinogram (bf ERG) parameters showed a statistically significant difference of means between 4- and 8-week follow-up visits.Conclusion: Our experience with double filling in selected cases of retinal detachment has been positive. No electroretinographic signs of retinal toxicity and a low incidence of PVR reproliferation were observed.Keywords: double filling, proliferative vitreo-retinopathy, perfluoro-n-octane, polydimethyloxane, retinal detachment, retinal detachment electrophysiology Zenoni SRomano MRPalmieri SComi NFiorentini EFontana PDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 443-449 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Zenoni S Romano MR Palmieri S Comi N Fiorentini E Fontana P Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane
description	Stefano Zenoni1, Mario R Romano2, Sonia Palmieri1, Natalia Comi1, Edoardo Fiorentini1, Piero Fontana11Ospedali Riuniti di Bergamo, Bergamo, Italy; 2Istituto Clinico Humanitas IRCSS, Rozzano, Milan, ItalyObjective: The aim of the study was to evaluate the ocular tolerance and efficacy of double filling with perfluoro-n-octane (n-C8F18) (PFO) and polydimethyloxane (PDMS) as a temporary vitreous substitute in patients with retinal detachment complicated by proliferative vitreoretinopathy (PVR).Material and methods: Tamponade was performed in 30 eyes of 30 patients by double filling with 30% PFO and 70% PDMS for an average of 23 (standard deviation 2.2) days. The follow-up visits were scheduled 1 week, 1 month, and 3 months after surgery. The main outcome measures were visual acuity, intraocular pressure (IOP), PVR reproliferation, and electrophysiological parameters.Results: The primary success rate was 80% (24/30). Fourteen patients (46.7%) had a postoperative improvement in visual acuity, 12 patients (40.0%) maintained their preoperative visual acuity, and four patients (13.3%) experienced a reduction in visual acuity. The mean postoperative IOP was 19.7 mm Hg (11&ndash;32 mm Hg); nine cases (30.0%) developed an IOP increase that was treated with topical drops and/or systemic carbonic anhydrase inhibitors. The electroretinogram (ERG) and the bright flash electroretinogram (bf ERG) parameters showed a statistically significant difference of means between 4- and 8-week follow-up visits.Conclusion: Our experience with double filling in selected cases of retinal detachment has been positive. No electroretinographic signs of retinal toxicity and a low incidence of PVR reproliferation were observed.Keywords: double filling, proliferative vitreo-retinopathy, perfluoro-n-octane, polydimethyloxane, retinal detachment, retinal detachment electrophysiology
format	article
author	Zenoni S Romano MR Palmieri S Comi N Fiorentini E Fontana P
author_facet	Zenoni S Romano MR Palmieri S Comi N Fiorentini E Fontana P
author_sort	Zenoni S
title	Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane
title_short	Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane
title_full	Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane
title_fullStr	Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane
title_full_unstemmed	Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane
title_sort	ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/da19d70c32ef4f768230d33295dea7c2
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Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane

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