Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats

Introduction: camphorated p-chlorophenol is a chlorophenolic derivative commonly used as an intra-oral medication in endodontics. Scientific reports on its effects in arterial vascular smooth muscle and local blood flow regulation are scarce. Objective: to determine the effect of camphorated p-chlo...

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Autores principales:	Oscar Rodríguez-Reyes, Robert Patejdl, Thomas Noack, Ana Ibis Bosch-Nuñez, Liset María García-Riza
Formato:	article
Lenguaje:	ES
Publicado:	Centro Editorial Ciencias Médicas: CPICM Guantánamo 2021
Materias:	músculo liso vascular tensión muscular vasodilatación baño de órganos medicación intracanal p-clorofenol alcanforado Medicine R
Acceso en línea:	https://doaj.org/article/da1d184cdfb54639a548ecbba1aa5f61
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spelling	oai:doaj.org-article:da1d184cdfb54639a548ecbba1aa5f612021-11-03T17:26:58ZCamphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats1028-9933https://doaj.org/article/da1d184cdfb54639a548ecbba1aa5f612021-10-01T00:00:00Zhttp://www.revinfcientifica.sld.cu/index.php/ric/article/view/3616https://doaj.org/toc/1028-9933Introduction: camphorated p-chlorophenol is a chlorophenolic derivative commonly used as an intra-oral medication in endodontics. Scientific reports on its effects in arterial vascular smooth muscle and local blood flow regulation are scarce. Objective: to determine the effect of camphorated p-chlorophenol on the contractile dynamics of arterial vascular smooth muscle. Method: an experimental and preclinical research was conducted with the use of 14 aortic rings of Wistar rats. The rings were placed in an organ bath and preactivated with noradrenaline, and the tension developed by the vascular smooth muscle at different time intervals was recorded after induction of camphorated p-chlorophenol. Results: most of the vascular smooth muscle (51.4%) relaxed with the use of camphorated p-chlorophenol. The greatest decrease in vascular tone occurred between the third and fifth minute after use the drug. Wilcoxon rank tests showed significant differences between tension observed at baseline and those recorded at the different time intervals studied. Conclusions: camphorated p-chlorophenol, induces in vitro, relax the arterial smooth muscle through a pharmacomechanical excitation-contraction link, which increases according to the time.Oscar Rodríguez-ReyesRobert PatejdlThomas NoackAna Ibis Bosch-NuñezLiset María García-RizaCentro Editorial Ciencias Médicas: CPICM Guantánamoarticlemúsculo liso vasculartensión muscularvasodilataciónbaño de órganosmedicación intracanalp-clorofenol alcanforadoMedicineRESRevista Información Científica, Vol 100, Iss 5, Pp e3616-e3616 (2021)
institution	DOAJ
collection	DOAJ
language	ES
topic	músculo liso vascular tensión muscular vasodilatación baño de órganos medicación intracanal p-clorofenol alcanforado Medicine R
spellingShingle	músculo liso vascular tensión muscular vasodilatación baño de órganos medicación intracanal p-clorofenol alcanforado Medicine R Oscar Rodríguez-Reyes Robert Patejdl Thomas Noack Ana Ibis Bosch-Nuñez Liset María García-Riza Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats
description	Introduction: camphorated p-chlorophenol is a chlorophenolic derivative commonly used as an intra-oral medication in endodontics. Scientific reports on its effects in arterial vascular smooth muscle and local blood flow regulation are scarce. Objective: to determine the effect of camphorated p-chlorophenol on the contractile dynamics of arterial vascular smooth muscle. Method: an experimental and preclinical research was conducted with the use of 14 aortic rings of Wistar rats. The rings were placed in an organ bath and preactivated with noradrenaline, and the tension developed by the vascular smooth muscle at different time intervals was recorded after induction of camphorated p-chlorophenol. Results: most of the vascular smooth muscle (51.4%) relaxed with the use of camphorated p-chlorophenol. The greatest decrease in vascular tone occurred between the third and fifth minute after use the drug. Wilcoxon rank tests showed significant differences between tension observed at baseline and those recorded at the different time intervals studied. Conclusions: camphorated p-chlorophenol, induces in vitro, relax the arterial smooth muscle through a pharmacomechanical excitation-contraction link, which increases according to the time.
format	article
author	Oscar Rodríguez-Reyes Robert Patejdl Thomas Noack Ana Ibis Bosch-Nuñez Liset María García-Riza
author_facet	Oscar Rodríguez-Reyes Robert Patejdl Thomas Noack Ana Ibis Bosch-Nuñez Liset María García-Riza
author_sort	Oscar Rodríguez-Reyes
title	Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats
title_short	Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats
title_full	Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats
title_fullStr	Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats
title_full_unstemmed	Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats
title_sort	camphorated p-chlorophenol-induced contractile dynamics in aortic rings of wistar rats
publisher	Centro Editorial Ciencias Médicas: CPICM Guantánamo
publishDate	2021
url	https://doaj.org/article/da1d184cdfb54639a548ecbba1aa5f61
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Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats

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