IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA

Abstract. We studied immunological state and activity of enzymes in blood lymphocytes from the patients at different stages of acute lymphoblastic leukemia. We have revealed that immune state in all the patients was characterized by decreased contents of T-lymphocytes. Upon first attack of the disea...

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Autores principales:	O. V. Smirnova, V. T. Manchouk, A. A. Savchenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunity acute lymphoblastic leukemia enzymes activity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/da1e1f9e8b164d6e867ecd4b3861530b
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spelling	oai:doaj.org-article:da1e1f9e8b164d6e867ecd4b3861530b2021-11-18T08:03:39ZIMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA1563-06252313-741X10.15789/1563-0625-2008-6-543-550https://doaj.org/article/da1e1f9e8b164d6e867ecd4b3861530b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/265https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We studied immunological state and activity of enzymes in blood lymphocytes from the patients at different stages of acute lymphoblastic leukemia. We have revealed that immune state in all the patients was characterized by decreased contents of T-lymphocytes. Upon first attack of the disease, they showed a decrease in CD4+cells, as well as increased concentration of IgM and IgG. During remission, we have found the lowest values of all the parameters under study. In relapsing patients, high content of NK-cells, and imbalance between the main Ig classes were noted. When studying metabolism of lymphocyte, it was revealed that, in first attack and relapse phase, both intensity of anaerobic glucose oxidation, and levels of macromolecular synthetic reactions were decreased. In remission, all these processes did recover to normal range. At all stages of disease, glutathione reductase activity was found to be decreased in blood lymphocytes. (Med. Immunol., vol. 10, N 6, pp 543-550).O. V. SmirnovaV. T. ManchoukA. A. SavchenkoSPb RAACIarticleimmunityacute lymphoblastic leukemiaenzymes activityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 6, Pp 543-550 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunity acute lymphoblastic leukemia enzymes activity Immunologic diseases. Allergy RC581-607
spellingShingle	immunity acute lymphoblastic leukemia enzymes activity Immunologic diseases. Allergy RC581-607 O. V. Smirnova V. T. Manchouk A. A. Savchenko IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA
description	Abstract. We studied immunological state and activity of enzymes in blood lymphocytes from the patients at different stages of acute lymphoblastic leukemia. We have revealed that immune state in all the patients was characterized by decreased contents of T-lymphocytes. Upon first attack of the disease, they showed a decrease in CD4+cells, as well as increased concentration of IgM and IgG. During remission, we have found the lowest values of all the parameters under study. In relapsing patients, high content of NK-cells, and imbalance between the main Ig classes were noted. When studying metabolism of lymphocyte, it was revealed that, in first attack and relapse phase, both intensity of anaerobic glucose oxidation, and levels of macromolecular synthetic reactions were decreased. In remission, all these processes did recover to normal range. At all stages of disease, glutathione reductase activity was found to be decreased in blood lymphocytes. (Med. Immunol., vol. 10, N 6, pp 543-550).
format	article
author	O. V. Smirnova V. T. Manchouk A. A. Savchenko
author_facet	O. V. Smirnova V. T. Manchouk A. A. Savchenko
author_sort	O. V. Smirnova
title	IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA
title_short	IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA
title_full	IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA
title_fullStr	IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA
title_full_unstemmed	IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA
title_sort	immune profile and enzymes activity state in blood lymphocytes in patients of different stages acute lymphoblast leukemia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/da1e1f9e8b164d6e867ecd4b3861530b
work_keys_str_mv	AT ovsmirnova immuneprofileandenzymesactivitystateinbloodlymphocytesinpatientsofdifferentstagesacutelymphoblastleukemia AT vtmanchouk immuneprofileandenzymesactivitystateinbloodlymphocytesinpatientsofdifferentstagesacutelymphoblastleukemia AT aasavchenko immuneprofileandenzymesactivitystateinbloodlymphocytesinpatientsofdifferentstagesacutelymphoblastleukemia
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IMMUNE PROFILE AND ENZYMES ACTIVITY STATE IN BLOOD LYMPHOCYTES IN PATIENTS OF DIFFERENT STAGES ACUTE LYMPHOBLAST LEUKEMIA

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