Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients

Aim. To identify the clinical and metabolic factors associated with serum concentration of high sensitivity C-reactive protein (hsCRP) and α1-acid glycoprotein (α1-AGP) in patients with type 2 diabetes.Material and methods. The study involved 210 patients with type 2 diabetes. Levels of hsCRP and α1...

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Autores principales:	Vadim V. Klimontov, Nadezda V. Tyan, Olga N. Fazullina, Natalia E. Myakina, Alexander P. Lykov, Vladimir I. Konenkov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	diabetes obesity inflammation glucose variability acute-phase proteins Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/da1faa5c7f264d11ad42e1e80250f4ca
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spelling	oai:doaj.org-article:da1faa5c7f264d11ad42e1e80250f4ca2021-11-14T09:00:20ZClinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients2072-03512072-037810.14341/DM7928https://doaj.org/article/da1faa5c7f264d11ad42e1e80250f4ca2016-11-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7928https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To identify the clinical and metabolic factors associated with serum concentration of high sensitivity C-reactive protein (hsCRP) and α1-acid glycoprotein (α1-AGP) in patients with type 2 diabetes.Material and methods. The study involved 210 patients with type 2 diabetes. Levels of hsCRP and α1-AGP were measured using ELISA and compared with those of the control (30 healthy normal individuals). Levels of acute-phase proteins, fat mass and glucose variability (GV) were compared among demographic, anthropometric, biochemical and haematological parameters. The fat mass was determined with Dual-energy X-ray absorptiometry (DEXA). GV parameters including mean amplitude of glycaemic excursions, continuous overlapping net glycaemic action (CONGA), J-index, M-value and mean absolute glucose change (MAG) were derived from continuous glucose monitoring.Results. Levels of hsCRP and α1-AGP significantly increased (p < 0.0001) in patients with diabetes compared with controls. hsCRP level positively correlated with total, truncal and android fat (r = 0.34, r = 0.28 and r = 0.31; respectively, p < 0.00004). α1-AGP level showed no relationship with fat mass but positively correlated with mean glucose, CONGA, M-value and MAG (r = 0.38, r = 0.36, r = 0.43 and r = 0.4; respectively, p < 0.0001). Patients with the highest hsCRP levels (>75 percentile) had a greater body mass index (p = 0.00009) as well as truncal and android fat mass (p = 0.04 and p = 0.03, respectively) than those with the lowest levels (<25 percentile). High level of α1-AGP (>75 percentile) was associated with urinary albumin/creatinine ratio (p = 0.01) and GV indices (M-value: p = 0.02, MAG: p = 0.04).Conclusions. Levels of acute-phase proteins (hsCRP and α1-AGP) increased in patients with type 2 diabetes. Levels of hsCRP were associated with fat mass; meanwhile, α1-AGP levels were associated with short-time GV in these patients. The results lend support to the notion that both obesity and enhanced GV are involved in the development of chronic low-grade inflammation associated with type 2 diabetes.Vadim V. KlimontovNadezda V. TyanOlga N. FazullinaNatalia E. MyakinaAlexander P. LykovVladimir I. KonenkovEndocrinology Research Centrearticlediabetesobesityinflammationglucose variabilityacute-phase proteinsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 4, Pp 295-302 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes obesity inflammation glucose variability acute-phase proteins Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes obesity inflammation glucose variability acute-phase proteins Nutritional diseases. Deficiency diseases RC620-627 Vadim V. Klimontov Nadezda V. Tyan Olga N. Fazullina Natalia E. Myakina Alexander P. Lykov Vladimir I. Konenkov Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients
description	Aim. To identify the clinical and metabolic factors associated with serum concentration of high sensitivity C-reactive protein (hsCRP) and α1-acid glycoprotein (α1-AGP) in patients with type 2 diabetes.Material and methods. The study involved 210 patients with type 2 diabetes. Levels of hsCRP and α1-AGP were measured using ELISA and compared with those of the control (30 healthy normal individuals). Levels of acute-phase proteins, fat mass and glucose variability (GV) were compared among demographic, anthropometric, biochemical and haematological parameters. The fat mass was determined with Dual-energy X-ray absorptiometry (DEXA). GV parameters including mean amplitude of glycaemic excursions, continuous overlapping net glycaemic action (CONGA), J-index, M-value and mean absolute glucose change (MAG) were derived from continuous glucose monitoring.Results. Levels of hsCRP and α1-AGP significantly increased (p < 0.0001) in patients with diabetes compared with controls. hsCRP level positively correlated with total, truncal and android fat (r = 0.34, r = 0.28 and r = 0.31; respectively, p < 0.00004). α1-AGP level showed no relationship with fat mass but positively correlated with mean glucose, CONGA, M-value and MAG (r = 0.38, r = 0.36, r = 0.43 and r = 0.4; respectively, p < 0.0001). Patients with the highest hsCRP levels (>75 percentile) had a greater body mass index (p = 0.00009) as well as truncal and android fat mass (p = 0.04 and p = 0.03, respectively) than those with the lowest levels (<25 percentile). High level of α1-AGP (>75 percentile) was associated with urinary albumin/creatinine ratio (p = 0.01) and GV indices (M-value: p = 0.02, MAG: p = 0.04).Conclusions. Levels of acute-phase proteins (hsCRP and α1-AGP) increased in patients with type 2 diabetes. Levels of hsCRP were associated with fat mass; meanwhile, α1-AGP levels were associated with short-time GV in these patients. The results lend support to the notion that both obesity and enhanced GV are involved in the development of chronic low-grade inflammation associated with type 2 diabetes.
format	article
author	Vadim V. Klimontov Nadezda V. Tyan Olga N. Fazullina Natalia E. Myakina Alexander P. Lykov Vladimir I. Konenkov
author_facet	Vadim V. Klimontov Nadezda V. Tyan Olga N. Fazullina Natalia E. Myakina Alexander P. Lykov Vladimir I. Konenkov
author_sort	Vadim V. Klimontov
title	Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients
title_short	Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients
title_full	Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients
title_fullStr	Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients
title_full_unstemmed	Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients
title_sort	clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/da1faa5c7f264d11ad42e1e80250f4ca
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Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients

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