Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.

IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide. Pediatric patients in Japan are diagnosed with IgAN at an early stage of the disease through annual urinary examinations. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor-inducibl...

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Autores principales:	Yuko Tezuka, Minenori Eguchi-Ishimae, Erina Ozaki, Toshiyuki Ito, Eiichi Ishii, Mariko Eguchi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da23f454b417490db15d5e5926ce0768
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spelling	oai:doaj.org-article:da23f454b417490db15d5e5926ce07682021-12-02T20:17:24ZActivation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.1932-620310.1371/journal.pone.0258090https://doaj.org/article/da23f454b417490db15d5e5926ce07682021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258090https://doaj.org/toc/1932-6203IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide. Pediatric patients in Japan are diagnosed with IgAN at an early stage of the disease through annual urinary examinations. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor-inducible 14 (Fn14) have various roles, including proinflammatory effects, and modulation of several kidney diseases; however, no reports have described their roles in pediatric IgAN. In this study, we performed pathological and immunohistochemical analyses of samples from 14 pediatric IgAN patients. Additionally, gene expression arrays of glomeruli by laser-captured microdissection were performed in hemi-nephrectomized high serum IgA (HIGA) mice, a model of IgA nephropathy, to determine the role of Fn14. Glomeruli with intense Fn14 deposition were observed in 80% of mild IgAN cases; however, most severe cases showed glomeruli with little or no Fn14 deposition. Fn14 deposition was not observed in obvious mesangial proliferation or the crescent region of glomeruli, but was detected strongly in the glomerular tuft, with an intact appearance. In HIGA mice, Fn14 deposition was observed mildly beginning at 11 weeks of age, and stronger Fn14 deposition was detected at 14 weeks of age. Expression array analysis indicated that Fn14 expression was higher in HIGA mice at 6 weeks of age, increased slightly at 11 weeks, and then decreased at 26 weeks when compared with controls at equivalent ages. These findings suggest that Fn14 signaling affects early lesions but not advanced lesions in patients with IgAN. Further study of the TWEAK/Fn14 pathway will contribute to our understanding of the progression of IgAN.Yuko TezukaMinenori Eguchi-IshimaeErina OzakiToshiyuki ItoEiichi IshiiMariko EguchiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258090 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuko Tezuka Minenori Eguchi-Ishimae Erina Ozaki Toshiyuki Ito Eiichi Ishii Mariko Eguchi Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.
description	IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide. Pediatric patients in Japan are diagnosed with IgAN at an early stage of the disease through annual urinary examinations. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor-inducible 14 (Fn14) have various roles, including proinflammatory effects, and modulation of several kidney diseases; however, no reports have described their roles in pediatric IgAN. In this study, we performed pathological and immunohistochemical analyses of samples from 14 pediatric IgAN patients. Additionally, gene expression arrays of glomeruli by laser-captured microdissection were performed in hemi-nephrectomized high serum IgA (HIGA) mice, a model of IgA nephropathy, to determine the role of Fn14. Glomeruli with intense Fn14 deposition were observed in 80% of mild IgAN cases; however, most severe cases showed glomeruli with little or no Fn14 deposition. Fn14 deposition was not observed in obvious mesangial proliferation or the crescent region of glomeruli, but was detected strongly in the glomerular tuft, with an intact appearance. In HIGA mice, Fn14 deposition was observed mildly beginning at 11 weeks of age, and stronger Fn14 deposition was detected at 14 weeks of age. Expression array analysis indicated that Fn14 expression was higher in HIGA mice at 6 weeks of age, increased slightly at 11 weeks, and then decreased at 26 weeks when compared with controls at equivalent ages. These findings suggest that Fn14 signaling affects early lesions but not advanced lesions in patients with IgAN. Further study of the TWEAK/Fn14 pathway will contribute to our understanding of the progression of IgAN.
format	article
author	Yuko Tezuka Minenori Eguchi-Ishimae Erina Ozaki Toshiyuki Ito Eiichi Ishii Mariko Eguchi
author_facet	Yuko Tezuka Minenori Eguchi-Ishimae Erina Ozaki Toshiyuki Ito Eiichi Ishii Mariko Eguchi
author_sort	Yuko Tezuka
title	Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.
title_short	Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.
title_full	Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.
title_fullStr	Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.
title_full_unstemmed	Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.
title_sort	activation of fibroblast growth factor-inducible 14 in the early phase of childhood iga nephropathy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/da23f454b417490db15d5e5926ce0768
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Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy.

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