Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox

Abstract Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	B. Ogunjimi, J. Van den Bergh, P. Meysman, S. Heynderickx, K. Bergs, H. Jansens, E. Leuridan, A. Vorsters, H. Goossens, K. Laukens, N. Cools, Viggo Van Tendeloo, N. Hens, P. Van Damme, Evelien Smits, Ph. Beutels
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da25d5c449f3410083345291595df30c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:da25d5c449f3410083345291595df30c
record_format	dspace
spelling	oai:doaj.org-article:da25d5c449f3410083345291595df30c2021-12-02T11:40:41ZMultidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox10.1038/s41598-017-01024-82045-2322https://doaj.org/article/da25d5c449f3410083345291595df30c2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01024-8https://doaj.org/toc/2045-2322Abstract Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting 183 samples and those of 14 controls were assessed for VZV-specific T-cell immunity and antibody titres. The percentages of VZV-specific CD4+ IL-2-producing T-cells were increased in re-exposed grandparents compared to control participants up to 9 months after re-exposure. Using a longitudinal mixture modelling approach, we found that 25% and 17% of re-exposed grandparents showed a boosting of VZV-specific CD4+ IL-2-producing T-cells and VZV-specific antibodies, respectively. The antibody boosting occurred exclusively in cytomegalovirus (CMV) IgG-positive participants. CMV IgG-positive participants also had higher VZV IE62-specific CD4+ IFN-γ-producing T-cell percentages and VZV-specific antibody titres. The protective effect of re-exposure to chickenpox is likely limited, as boosting only occurred in 17–25% of the VZV re-exposed grandparents and for less than one year.B. OgunjimiJ. Van den BerghP. MeysmanS. HeynderickxK. BergsH. JansensE. LeuridanA. VorstersH. GoossensK. LaukensN. CoolsViggo Van TendelooN. HensP. Van DammeEvelien SmitsPh. BeutelsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q B. Ogunjimi J. Van den Bergh P. Meysman S. Heynderickx K. Bergs H. Jansens E. Leuridan A. Vorsters H. Goossens K. Laukens N. Cools Viggo Van Tendeloo N. Hens P. Van Damme Evelien Smits Ph. Beutels Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
description	Abstract Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting 183 samples and those of 14 controls were assessed for VZV-specific T-cell immunity and antibody titres. The percentages of VZV-specific CD4+ IL-2-producing T-cells were increased in re-exposed grandparents compared to control participants up to 9 months after re-exposure. Using a longitudinal mixture modelling approach, we found that 25% and 17% of re-exposed grandparents showed a boosting of VZV-specific CD4+ IL-2-producing T-cells and VZV-specific antibodies, respectively. The antibody boosting occurred exclusively in cytomegalovirus (CMV) IgG-positive participants. CMV IgG-positive participants also had higher VZV IE62-specific CD4+ IFN-γ-producing T-cell percentages and VZV-specific antibody titres. The protective effect of re-exposure to chickenpox is likely limited, as boosting only occurred in 17–25% of the VZV re-exposed grandparents and for less than one year.
format	article
author	B. Ogunjimi J. Van den Bergh P. Meysman S. Heynderickx K. Bergs H. Jansens E. Leuridan A. Vorsters H. Goossens K. Laukens N. Cools Viggo Van Tendeloo N. Hens P. Van Damme Evelien Smits Ph. Beutels
author_facet	B. Ogunjimi J. Van den Bergh P. Meysman S. Heynderickx K. Bergs H. Jansens E. Leuridan A. Vorsters H. Goossens K. Laukens N. Cools Viggo Van Tendeloo N. Hens P. Van Damme Evelien Smits Ph. Beutels
author_sort	B. Ogunjimi
title	Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
title_short	Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
title_full	Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
title_fullStr	Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
title_full_unstemmed	Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
title_sort	multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/da25d5c449f3410083345291595df30c
work_keys_str_mv	AT bogunjimi multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT jvandenbergh multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT pmeysman multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT sheynderickx multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT kbergs multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT hjansens multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT eleuridan multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT avorsters multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT hgoossens multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT klaukens multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT ncools multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT viggovantendeloo multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT nhens multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT pvandamme multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT eveliensmits multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox AT phbeutels multidisciplinarystudyofthesecondaryimmuneresponseingrandparentsreexposedtochickenpox
_version_	1718395611833696256

Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox

Ejemplares similares