Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery

Abstract Open heart surgeries are common for treating ischemic and heart valve disease. During cardiac surgery, cardiopulmonary bypass (CPB) can temporarily take over the function of heart and lungs. However, elevated red blood cell (RBC) aggregation may lead to the common side-effects such as micro...

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Autores principales:	Yi-Fan Wu, Po-Shun Hsu, Chien-Sung Tsai, Pin-Cheng Pan, Yeng-Long Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da265142f97241c18576f6259b98e074
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spelling	oai:doaj.org-article:da265142f97241c18576f6259b98e0742021-12-02T15:08:42ZSignificantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery10.1038/s41598-018-25317-82045-2322https://doaj.org/article/da265142f97241c18576f6259b98e0742018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25317-8https://doaj.org/toc/2045-2322Abstract Open heart surgeries are common for treating ischemic and heart valve disease. During cardiac surgery, cardiopulmonary bypass (CPB) can temporarily take over the function of heart and lungs. However, elevated red blood cell (RBC) aggregation may lead to the common side-effects such as microinfarction. We investigated blood physical properties changes and the correlation between blood microstructure, viscoelastic response and biochemical changes following surgery with CPB. We examined shear-rate dependent blood viscosity, elasticity and RBC aggregate size in the pre-surgery disease state, post-surgery state and long-term recovery state of cardiac surgical patients. Within a week following surgery, the patient hematocrit was significantly lower due to CPB. Despite lower RBC concentration, the RBC aggregate shape became larger and more rounded, which is correlated to the elevated plasma fibrinogen related to systemic inflammatory response. During the same period, the hematocrit-adjusted low shear rate viscosity increased significantly, as did the yield stress, indicating more solid-like behavior for blood. Six months to one year later, all the physical and biochemical properties measured returned to baseline.Yi-Fan WuPo-Shun HsuChien-Sung TsaiPin-Cheng PanYeng-Long ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Fan Wu Po-Shun Hsu Chien-Sung Tsai Pin-Cheng Pan Yeng-Long Chen Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery
description	Abstract Open heart surgeries are common for treating ischemic and heart valve disease. During cardiac surgery, cardiopulmonary bypass (CPB) can temporarily take over the function of heart and lungs. However, elevated red blood cell (RBC) aggregation may lead to the common side-effects such as microinfarction. We investigated blood physical properties changes and the correlation between blood microstructure, viscoelastic response and biochemical changes following surgery with CPB. We examined shear-rate dependent blood viscosity, elasticity and RBC aggregate size in the pre-surgery disease state, post-surgery state and long-term recovery state of cardiac surgical patients. Within a week following surgery, the patient hematocrit was significantly lower due to CPB. Despite lower RBC concentration, the RBC aggregate shape became larger and more rounded, which is correlated to the elevated plasma fibrinogen related to systemic inflammatory response. During the same period, the hematocrit-adjusted low shear rate viscosity increased significantly, as did the yield stress, indicating more solid-like behavior for blood. Six months to one year later, all the physical and biochemical properties measured returned to baseline.
format	article
author	Yi-Fan Wu Po-Shun Hsu Chien-Sung Tsai Pin-Cheng Pan Yeng-Long Chen
author_facet	Yi-Fan Wu Po-Shun Hsu Chien-Sung Tsai Pin-Cheng Pan Yeng-Long Chen
author_sort	Yi-Fan Wu
title	Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery
title_short	Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery
title_full	Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery
title_fullStr	Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery
title_full_unstemmed	Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery
title_sort	significantly increased low shear rate viscosity, blood elastic modulus, and rbc aggregation in adults following cardiac surgery
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/da265142f97241c18576f6259b98e074
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Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery

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