Comparative Study between Vitamin D and Placebo in Patients with Nasal Polyps

Background: Chronic rhino-sinusitis with nasal polyps [CRSwNP] is a prevalent disease that has an important influence on patient quality of life. Vitamin D3 [VD3] has been shown to suppress the proliferation of fibroblasts generated from nasal polyps.Aim of the work: The aim of this work is to evalu...

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Autores principales:	Ahmed Sobhi Abdelaal, Salah Saleh Elhadidy, Mohamed Abd-Elkafy Ibrahim
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	chronic rhino sinusitis vitamin d3 nasal polyps disease severity endoscopic meltzer score Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/da272bbc80c349988a2a982c341d84bc
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spelling	oai:doaj.org-article:da272bbc80c349988a2a982c341d84bc2021-12-02T19:36:37ZComparative Study between Vitamin D and Placebo in Patients with Nasal Polyps2636-41742682-378010.21608/ijma.2021.86879.1345https://doaj.org/article/da272bbc80c349988a2a982c341d84bc2021-10-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_196588_538006a07f10e281bfb3a41d9740430e.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Chronic rhino-sinusitis with nasal polyps [CRSwNP] is a prevalent disease that has an important influence on patient quality of life. Vitamin D3 [VD3] has been shown to suppress the proliferation of fibroblasts generated from nasal polyps.Aim of the work: The aim of this work is to evaluate the safety and efficacy of vitamin D3 in decreasing the severity and size of sino-nasal polyps in patients with vitamin D3 insufficiency.Methods: This study is a prospective cohort study conducted on 46 patients with chronic rhino-sinusitis with nasal polyps with vitamin D3 insufficiency [low levels of vitamin D3 < 30 ng/ml]. Included patients were divided into 2 groups, the first group were 22 patients given vitamin D3 [200,000 IU] intramuscular [IM], and the other control group included 20 patients were given placebo in the same manner as the first group. The two groups were assessed before vitamin D3 and placebo supplementation and after 3 months with endoscopic Meltzer grading score and CT scan.Results: Based on endoscopic Meltzer scores, there was improvement among 68.3% of vitamin D3 group vs. 20% of the placebo group; the severity of sino-nasal polyps was observed to be considerably reduced in vitamin D3 group in comparison to placebo group. CT finding reported 40.9% of vitamin D3 group improved vs. 10% of placebo group], the improvement of CT was changing of the affected sinuses from complete to partial opacification.Conclusion: Vitamin D3 has an effective way in lowering the severity of nasal polyps and alleviating their manifestations.Ahmed Sobhi AbdelaalSalah Saleh ElhadidyMohamed Abd-Elkafy IbrahimAl-Azhar University, Faculty of Medicine (Damietta)articlechronic rhino sinusitisvitamin d3nasal polypsdisease severityendoscopic meltzer scoreMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 4, Pp 1849-1854 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic rhino sinusitis vitamin d3 nasal polyps disease severity endoscopic meltzer score Medicine (General) R5-920
spellingShingle	chronic rhino sinusitis vitamin d3 nasal polyps disease severity endoscopic meltzer score Medicine (General) R5-920 Ahmed Sobhi Abdelaal Salah Saleh Elhadidy Mohamed Abd-Elkafy Ibrahim Comparative Study between Vitamin D and Placebo in Patients with Nasal Polyps
description	Background: Chronic rhino-sinusitis with nasal polyps [CRSwNP] is a prevalent disease that has an important influence on patient quality of life. Vitamin D3 [VD3] has been shown to suppress the proliferation of fibroblasts generated from nasal polyps.Aim of the work: The aim of this work is to evaluate the safety and efficacy of vitamin D3 in decreasing the severity and size of sino-nasal polyps in patients with vitamin D3 insufficiency.Methods: This study is a prospective cohort study conducted on 46 patients with chronic rhino-sinusitis with nasal polyps with vitamin D3 insufficiency [low levels of vitamin D3 < 30 ng/ml]. Included patients were divided into 2 groups, the first group were 22 patients given vitamin D3 [200,000 IU] intramuscular [IM], and the other control group included 20 patients were given placebo in the same manner as the first group. The two groups were assessed before vitamin D3 and placebo supplementation and after 3 months with endoscopic Meltzer grading score and CT scan.Results: Based on endoscopic Meltzer scores, there was improvement among 68.3% of vitamin D3 group vs. 20% of the placebo group; the severity of sino-nasal polyps was observed to be considerably reduced in vitamin D3 group in comparison to placebo group. CT finding reported 40.9% of vitamin D3 group improved vs. 10% of placebo group], the improvement of CT was changing of the affected sinuses from complete to partial opacification.Conclusion: Vitamin D3 has an effective way in lowering the severity of nasal polyps and alleviating their manifestations.
format	article
author	Ahmed Sobhi Abdelaal Salah Saleh Elhadidy Mohamed Abd-Elkafy Ibrahim
author_facet	Ahmed Sobhi Abdelaal Salah Saleh Elhadidy Mohamed Abd-Elkafy Ibrahim
author_sort	Ahmed Sobhi Abdelaal
title	Comparative Study between Vitamin D and Placebo in Patients with Nasal Polyps
title_short	Comparative Study between Vitamin D and Placebo in Patients with Nasal Polyps
title_full	Comparative Study between Vitamin D and Placebo in Patients with Nasal Polyps
title_fullStr	Comparative Study between Vitamin D and Placebo in Patients with Nasal Polyps
title_full_unstemmed	Comparative Study between Vitamin D and Placebo in Patients with Nasal Polyps
title_sort	comparative study between vitamin d and placebo in patients with nasal polyps
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/da272bbc80c349988a2a982c341d84bc
work_keys_str_mv	AT ahmedsobhiabdelaal comparativestudybetweenvitamindandplaceboinpatientswithnasalpolyps AT salahsalehelhadidy comparativestudybetweenvitamindandplaceboinpatientswithnasalpolyps AT mohamedabdelkafyibrahim comparativestudybetweenvitamindandplaceboinpatientswithnasalpolyps
_version_	1718376354030813184

Comparative Study between Vitamin D and Placebo in Patients with Nasal Polyps

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