BRD7 deficiency leads to the development of obesity and hyperglycemia

Abstract Obesity is a debilitating disease that has become a global epidemic. Although progress is being made, the underlying molecular mechanism by which obesity develops still remains elusive. Recently, we reported that the expression levels of bromodomain-containing protein 7 (BRD7) are significa...

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Autores principales:	Junsik M. Lee, Yoo Kim, Mario Andrés Salazar Hernández, Youngah Han, Renyan Liu, Sang Won Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da28870084354b9f9a1466d78d0b40ca
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spelling	oai:doaj.org-article:da28870084354b9f9a1466d78d0b40ca2021-12-02T15:09:39ZBRD7 deficiency leads to the development of obesity and hyperglycemia10.1038/s41598-019-41713-02045-2322https://doaj.org/article/da28870084354b9f9a1466d78d0b40ca2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-41713-0https://doaj.org/toc/2045-2322Abstract Obesity is a debilitating disease that has become a global epidemic. Although progress is being made, the underlying molecular mechanism by which obesity develops still remains elusive. Recently, we reported that the expression levels of bromodomain-containing protein 7 (BRD7) are significantly reduced in the liver of obese mice. However, it is not clear whether decreased levels of hepatic BRD7 are directly associated with the development of obesity and disturbance in glucose homeostasis. Here, using heterozygous BRD7 knockout and liver-specific BRD7 knockout mouse models, we report that reduced BRD7 levels lead to increased weight gain with little effect on glucose metabolism. On the other hand, upregulating BRD7 in the liver starting at an early age protects mice from gaining excessive weight and developing glucose intolerance and insulin resistance when challenged with a high-fat diet.Junsik M. LeeYoo KimMario Andrés Salazar HernándezYoungah HanRenyan LiuSang Won ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junsik M. Lee Yoo Kim Mario Andrés Salazar Hernández Youngah Han Renyan Liu Sang Won Park BRD7 deficiency leads to the development of obesity and hyperglycemia
description	Abstract Obesity is a debilitating disease that has become a global epidemic. Although progress is being made, the underlying molecular mechanism by which obesity develops still remains elusive. Recently, we reported that the expression levels of bromodomain-containing protein 7 (BRD7) are significantly reduced in the liver of obese mice. However, it is not clear whether decreased levels of hepatic BRD7 are directly associated with the development of obesity and disturbance in glucose homeostasis. Here, using heterozygous BRD7 knockout and liver-specific BRD7 knockout mouse models, we report that reduced BRD7 levels lead to increased weight gain with little effect on glucose metabolism. On the other hand, upregulating BRD7 in the liver starting at an early age protects mice from gaining excessive weight and developing glucose intolerance and insulin resistance when challenged with a high-fat diet.
format	article
author	Junsik M. Lee Yoo Kim Mario Andrés Salazar Hernández Youngah Han Renyan Liu Sang Won Park
author_facet	Junsik M. Lee Yoo Kim Mario Andrés Salazar Hernández Youngah Han Renyan Liu Sang Won Park
author_sort	Junsik M. Lee
title	BRD7 deficiency leads to the development of obesity and hyperglycemia
title_short	BRD7 deficiency leads to the development of obesity and hyperglycemia
title_full	BRD7 deficiency leads to the development of obesity and hyperglycemia
title_fullStr	BRD7 deficiency leads to the development of obesity and hyperglycemia
title_full_unstemmed	BRD7 deficiency leads to the development of obesity and hyperglycemia
title_sort	brd7 deficiency leads to the development of obesity and hyperglycemia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/da28870084354b9f9a1466d78d0b40ca
work_keys_str_mv	AT junsikmlee brd7deficiencyleadstothedevelopmentofobesityandhyperglycemia AT yookim brd7deficiencyleadstothedevelopmentofobesityandhyperglycemia AT marioandressalazarhernandez brd7deficiencyleadstothedevelopmentofobesityandhyperglycemia AT youngahhan brd7deficiencyleadstothedevelopmentofobesityandhyperglycemia AT renyanliu brd7deficiencyleadstothedevelopmentofobesityandhyperglycemia AT sangwonpark brd7deficiencyleadstothedevelopmentofobesityandhyperglycemia
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BRD7 deficiency leads to the development of obesity and hyperglycemia

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