Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer

Ruben AG van Eerden,1 Ron HJ Mathijssen,1 Stijn LW Koolen1,2 1Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands; 2Department of Hospital Pharmacy, Erasmus MC University Medical Center, Rotterdam, the NetherlandsCorrespondence: Ruben AG van EerdenDepartment of Me...

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Autores principales:	van Eerden RAG, Mathijssen RHJ, Koolen SLW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nanomedicine nanoparticle drug delivery systems taxane cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/da2b094e68184f01a02aca51e7ee3acb
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spelling	oai:doaj.org-article:da2b094e68184f01a02aca51e7ee3acb2021-12-02T15:28:42ZRecent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer1178-2013https://doaj.org/article/da2b094e68184f01a02aca51e7ee3acb2020-10-01T00:00:00Zhttps://www.dovepress.com/recent-clinical-developments-of-nanomediated-drug-delivery-systems-of--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ruben AG van Eerden,1 Ron HJ Mathijssen,1 Stijn LW Koolen1,2 1Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands; 2Department of Hospital Pharmacy, Erasmus MC University Medical Center, Rotterdam, the NetherlandsCorrespondence: Ruben AG van EerdenDepartment of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, the NetherlandsTel +31 10 7039640Email r.vaneerden@erasmusmc.nlAbstract: Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety of malignancies. Nevertheless, a large proportion of patients do not benefit from their treatment while they do suffer from severe adverse events related to the solvent or to the active compound. Cremophor EL and polysorbate 80 free formulations, conjugates, oral formulations and different types of drug delivery systems are some examples of the several attempts to improve the treatment with taxanes. In this review article, we discuss recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer. Targeting mechanisms of drug delivery systems and characteristics of the most commonly used taxane-containing drug delivery systems in the clinical setting will be discussed in this review.Keywords: nanomedicine, nanoparticle, drug delivery systems, taxane, cancervan Eerden RAGMathijssen RHJKoolen SLWDove Medical Pressarticlenanomedicinenanoparticledrug delivery systemstaxanecancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8151-8166 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomedicine nanoparticle drug delivery systems taxane cancer Medicine (General) R5-920
spellingShingle	nanomedicine nanoparticle drug delivery systems taxane cancer Medicine (General) R5-920 van Eerden RAG Mathijssen RHJ Koolen SLW Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
description	Ruben AG van Eerden,1 Ron HJ Mathijssen,1 Stijn LW Koolen1,2 1Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands; 2Department of Hospital Pharmacy, Erasmus MC University Medical Center, Rotterdam, the NetherlandsCorrespondence: Ruben AG van EerdenDepartment of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, the NetherlandsTel +31 10 7039640Email r.vaneerden@erasmusmc.nlAbstract: Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety of malignancies. Nevertheless, a large proportion of patients do not benefit from their treatment while they do suffer from severe adverse events related to the solvent or to the active compound. Cremophor EL and polysorbate 80 free formulations, conjugates, oral formulations and different types of drug delivery systems are some examples of the several attempts to improve the treatment with taxanes. In this review article, we discuss recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer. Targeting mechanisms of drug delivery systems and characteristics of the most commonly used taxane-containing drug delivery systems in the clinical setting will be discussed in this review.Keywords: nanomedicine, nanoparticle, drug delivery systems, taxane, cancer
format	article
author	van Eerden RAG Mathijssen RHJ Koolen SLW
author_facet	van Eerden RAG Mathijssen RHJ Koolen SLW
author_sort	van Eerden RAG
title	Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_short	Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_full	Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_fullStr	Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_full_unstemmed	Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_sort	recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/da2b094e68184f01a02aca51e7ee3acb
work_keys_str_mv	AT vaneerdenrag recentclinicaldevelopmentsofnanomediateddrugdeliverysystemsoftaxanesforthetreatmentofcancer AT mathijssenrhj recentclinicaldevelopmentsofnanomediateddrugdeliverysystemsoftaxanesforthetreatmentofcancer AT koolenslw recentclinicaldevelopmentsofnanomediateddrugdeliverysystemsoftaxanesforthetreatmentofcancer
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Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer

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