Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

Human T-lymphotropic virus type 1 (HTLV-1) is a neglected retrovirus distributed worldwide and the ethiological agent of several pathologies, such as adult T-cell leukemia/lymphoma (ATLL), a chronic myelopathy known as HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective...

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Autores principales:	Paula Benencio, Nicolás Ducasa, Lourdes Arruvito, Inés Irurzun, Laura Praino, Magdalena Lamberti, María Beraza, Carolina Berini, Mirna Biglione
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	infective dermatitis HTLV-1 pediatric antibiotic Argentina case report Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/da3070034feb47daa525efade37c3c52
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spelling	oai:doaj.org-article:da3070034feb47daa525efade37c3c522021-11-10T06:29:03ZCase Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood2296-858X10.3389/fmed.2021.758352https://doaj.org/article/da3070034feb47daa525efade37c3c522021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.758352/fullhttps://doaj.org/toc/2296-858XHuman T-lymphotropic virus type 1 (HTLV-1) is a neglected retrovirus distributed worldwide and the ethiological agent of several pathologies, such as adult T-cell leukemia/lymphoma (ATLL), a chronic myelopathy known as HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). HTLV-1 presents tropism for CD4+ T cells and induces deregulation of the cytokine profile. IDH is a severe, chronic superinfected eczema generally associated with Staphylococcus aureus and/or Streptococcus beta haemolyticus infection that responds partially to antibiotic therapy but prompt recurrence develops upon treatment withdrawal. IDH could be a risk factor for progression toward both HAM/TSP and ATLL and, similarly to other diseases associated with HTLV-1, it is sub-diagnosed particularly in non-endemic areas. Here, we present a case of IDH in a young boy living in Buenos Aires with symptoms since 2010, at the age of 5. HTLV-1 infection was suspected and confirmed in 2016. The patient exhibited chronic dermatosis with exudative eruption involving mainly the scalp, retroauricular regions, neck and abdomen. Clinical evaluations, routine laboratory tests, full blood count, and HTLV-1 diagnosis for this case are included.Paula BenencioNicolás DucasaLourdes ArruvitoInés IrurzunLaura PrainoMagdalena LambertiMaría BerazaCarolina BeriniMirna BiglioneFrontiers Media S.A.articleinfective dermatitisHTLV-1pediatricantibioticArgentinacase reportMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	infective dermatitis HTLV-1 pediatric antibiotic Argentina case report Medicine (General) R5-920
spellingShingle	infective dermatitis HTLV-1 pediatric antibiotic Argentina case report Medicine (General) R5-920 Paula Benencio Nicolás Ducasa Lourdes Arruvito Inés Irurzun Laura Praino Magdalena Lamberti María Beraza Carolina Berini Mirna Biglione Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood
description	Human T-lymphotropic virus type 1 (HTLV-1) is a neglected retrovirus distributed worldwide and the ethiological agent of several pathologies, such as adult T-cell leukemia/lymphoma (ATLL), a chronic myelopathy known as HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). HTLV-1 presents tropism for CD4+ T cells and induces deregulation of the cytokine profile. IDH is a severe, chronic superinfected eczema generally associated with Staphylococcus aureus and/or Streptococcus beta haemolyticus infection that responds partially to antibiotic therapy but prompt recurrence develops upon treatment withdrawal. IDH could be a risk factor for progression toward both HAM/TSP and ATLL and, similarly to other diseases associated with HTLV-1, it is sub-diagnosed particularly in non-endemic areas. Here, we present a case of IDH in a young boy living in Buenos Aires with symptoms since 2010, at the age of 5. HTLV-1 infection was suspected and confirmed in 2016. The patient exhibited chronic dermatosis with exudative eruption involving mainly the scalp, retroauricular regions, neck and abdomen. Clinical evaluations, routine laboratory tests, full blood count, and HTLV-1 diagnosis for this case are included.
format	article
author	Paula Benencio Nicolás Ducasa Lourdes Arruvito Inés Irurzun Laura Praino Magdalena Lamberti María Beraza Carolina Berini Mirna Biglione
author_facet	Paula Benencio Nicolás Ducasa Lourdes Arruvito Inés Irurzun Laura Praino Magdalena Lamberti María Beraza Carolina Berini Mirna Biglione
author_sort	Paula Benencio
title	Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood
title_short	Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood
title_full	Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood
title_fullStr	Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood
title_full_unstemmed	Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood
title_sort	case report: relevance of an accurate diagnosis and monitoring of infective dermatitis associated with human t-lymphotropic virus type 1 in childhood
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/da3070034feb47daa525efade37c3c52
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Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

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