Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients

Background: Rapid maxillary expansion (RME) is the standard treatment for correcting lateral maxillary defects commonly used in orthodontics. It is the most effective approach to increase maxillary width in clinical practice. At present, there are few studies on the level of molecular biology of pe...

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Autores principales:	Zhipeng Tang, Dongxue Mi, Hao Wu, Yanan Fu, Li Liu, Xuelin Chen, Yujia Dong, Weikun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Tehran University of Medical Sciences 2021
Materias:	Matrix metalloproteinase-8 Interleukin-6 Tumor necrosis factor-α Gingival crevicular fluid Rapid maxillary expansion Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/da327daaab0f4ec6b81e5be1e6a1f72d
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spelling	oai:doaj.org-article:da327daaab0f4ec6b81e5be1e6a1f72d2021-12-02T19:26:27ZChanges in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients10.18502/ijph.v50i10.74942251-60852251-6093https://doaj.org/article/da327daaab0f4ec6b81e5be1e6a1f72d2021-10-01T00:00:00Zhttps://ijph.tums.ac.ir/index.php/ijph/article/view/23972https://doaj.org/toc/2251-6085https://doaj.org/toc/2251-6093 Background: Rapid maxillary expansion (RME) is the standard treatment for correcting lateral maxillary defects commonly used in orthodontics. It is the most effective approach to increase maxillary width in clinical practice. At present, there are few studies on the level of molecular biology of periodontal tissue remodeling during RME. We aimed to investigate changes in matrix metalloproteinase (MMP)-8, interleukin (IL)-6 and tumor necrosis factor (TNF)-αin gingival crevicular fluid during RME. Methods: Patients admitted to Department of Stomatology, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang Province, China between Dec 2016 and Dec 2018 were enrolled, and randomly divided into the observation group (76 cases) and control group (62 cases). Periodontal clinical indicators were recorded. Gingival crevicular fluid was collected and the periodontal clinical indicators were recorded. The levels of MMP-8, IL-6 and TNF-α were determined by ELISA, and the contents of the two groups were compared. Results: The plaque index of the observation group was significantly higher than that of the baseline T0 (P< 0.05) from T4, and the increase in the control group started from T5. The general clinical data of the two groups showed that the white blood cell count of the observation group was higher than that of the control group. The levels of MMP-8, IL-6 and TNF-α were the highest at T2, followed by T3, and gradually decreased at T4, and T5, and the differences were significant (P<0.05). Conclusion: The changes in levels of MMP-8, IL-6 and TNF-α in adolescent patients during RME were related to the remodeling of periodontal tissue after RME. Zhipeng TangDongxue MiHao WuYanan FuLi LiuXuelin ChenYujia DongWeikun ZhangTehran University of Medical SciencesarticleMatrix metalloproteinase-8Interleukin-6Tumor necrosis factor-αGingival crevicular fluidRapid maxillary expansionPublic aspects of medicineRA1-1270ENIranian Journal of Public Health, Vol 50, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Matrix metalloproteinase-8 Interleukin-6 Tumor necrosis factor-α Gingival crevicular fluid Rapid maxillary expansion Public aspects of medicine RA1-1270
spellingShingle	Matrix metalloproteinase-8 Interleukin-6 Tumor necrosis factor-α Gingival crevicular fluid Rapid maxillary expansion Public aspects of medicine RA1-1270 Zhipeng Tang Dongxue Mi Hao Wu Yanan Fu Li Liu Xuelin Chen Yujia Dong Weikun Zhang Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients
description	Background: Rapid maxillary expansion (RME) is the standard treatment for correcting lateral maxillary defects commonly used in orthodontics. It is the most effective approach to increase maxillary width in clinical practice. At present, there are few studies on the level of molecular biology of periodontal tissue remodeling during RME. We aimed to investigate changes in matrix metalloproteinase (MMP)-8, interleukin (IL)-6 and tumor necrosis factor (TNF)-αin gingival crevicular fluid during RME. Methods: Patients admitted to Department of Stomatology, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang Province, China between Dec 2016 and Dec 2018 were enrolled, and randomly divided into the observation group (76 cases) and control group (62 cases). Periodontal clinical indicators were recorded. Gingival crevicular fluid was collected and the periodontal clinical indicators were recorded. The levels of MMP-8, IL-6 and TNF-α were determined by ELISA, and the contents of the two groups were compared. Results: The plaque index of the observation group was significantly higher than that of the baseline T0 (P< 0.05) from T4, and the increase in the control group started from T5. The general clinical data of the two groups showed that the white blood cell count of the observation group was higher than that of the control group. The levels of MMP-8, IL-6 and TNF-α were the highest at T2, followed by T3, and gradually decreased at T4, and T5, and the differences were significant (P<0.05). Conclusion: The changes in levels of MMP-8, IL-6 and TNF-α in adolescent patients during RME were related to the remodeling of periodontal tissue after RME.
format	article
author	Zhipeng Tang Dongxue Mi Hao Wu Yanan Fu Li Liu Xuelin Chen Yujia Dong Weikun Zhang
author_facet	Zhipeng Tang Dongxue Mi Hao Wu Yanan Fu Li Liu Xuelin Chen Yujia Dong Weikun Zhang
author_sort	Zhipeng Tang
title	Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients
title_short	Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients
title_full	Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients
title_fullStr	Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients
title_full_unstemmed	Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients
title_sort	changes in matrix metalloproteinase-8, interleukin-6 and tumor necrosis factor-α in gingival crevicular fluid during rapid maxillary expansion in adolescent patients
publisher	Tehran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/da327daaab0f4ec6b81e5be1e6a1f72d
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Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tumor Necrosis Factor-Α in Gingival Crevicular Fluid during Rapid Maxillary Expansion in Adolescent Patients

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